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Alzheimer’s Disease Drugs Can Also Fight Antibiotic Resistance

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Pseudomonas aeruginosa is a bacterium that can evolve to resist antibiotics. “Nightmare bacteria” with unusual resistance to last resort antibiotics were discovered more than 200 times in the United States last year. (Illustration by CDC)

(CN) — A new study is uniquely effective in treating life-threatening bacteria, where drugs previously made to help fight Alzheimer’s disease have become more resistant to conventional antibiotics over time. It suggests that it may be.

The ability to target antibiotics and dangerous bacteria in the body has long been recognized as one of the most powerful tools in the fight against human disease, but it still has one major drawback. Certain strains have evolved their natural tolerance to antibiotics as they become cheaper, more accessible, and more and more dependent on them to continue to be humans around the world. Bacterial resistance to antibiotics is so strong that antibiotic treatments against these strains are essentially ineffective and can be wasted.

Developed by some bacteria, this natural shield (known as antimicrobial resistance) is widely recognized as a significant threat to the future of antibiotics and how healthcare professionals use them. ..

Mark Walker, Professor University of QueenslandSays that as more super bugs and illnesses become less vulnerable to the power of modern medicine, the treatment of people with severe infections has become a serious and potentially dire problem. ..

“The emergence of antibiotic-resistant superbug is an urgent threat to human health and impairs the ability to treat patients with serious infections,” Walker said at a news conference. “There is an urgent need for alternative strategies to treat such multidrug-resistant strains.”

However, researchers report that there is some hope on the horizon. In a new study published Wednesday at Science Translational Medicine, researchers show that drugs designed to help treat Alzheimer’s disease are also promising forms of treatment for antibiotic-resistant strains.

Through a series of experiments in mice, researchers found that a drug known as PBT2 was pneumonia, bloodstream infections, and meningitis.

A study on Wednesday reveals that PBT2 achieves this medical feat by destroying a series of important metals in bacteria. When these metals become unavailable, the mechanism of antibiotic resistance within these strains is significantly weakened, and antibiotic treatment becomes viable again.

This ability to fight Gram-negative bacteria has not yet been proven in humans, but researchers have found that if the success found in mice can be replicated, PBT2 will be in the ongoing fight of health professionals against increased antibiotic-resistant infections. I’m optimistic that I can represent a big victory all over the world.

Future research on the effectiveness of PBT2 for treating antimicrobial resistance is needed, but part of what makes Wednesday’s announcement so important is that it has already gone through many stages of rigorous testing. Researchers say it involves drugs. Several clinical studies have already been conducted to investigate drug results and prove that PBT2 is safe for humans.

Researchers report that this method of diverting drugs previously manufactured for a variety of treatments deserves recognition as a safe option for developing new drugs. By discovering new value in drugs that have already been created, researchers can save a great deal of time and money that would have been spent making drugs from scratch. Of course, researchers can avoid many of the risks associated with drug innovation.

Christopher McDavid, Associate Professor University of MelbourneThe future of antibiotic resistance may be a daunting path if current trends and estimates are stable, but Wednesday’s progress is needed for scientists to divert at such critical times. May give you a great advantage.

“New technology is essential to address this building’s threat to human health. This remedy is an additional weapon as a weapon to combat the accelerating threat of antibiotic resistance,” McDavid said. Stated. “If these new solutions are not developed, it is estimated that by 2050, antibiotic-resistant strains will kill more than 10 million people annually. This new treatment will change the course of antibiotic resistance. May be useful. “

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