Studies suggest that taking vitamin D supplements may reduce the overall risk of developing advanced cancer by 17%.
Researchers also report that the risk of metastatic (cancer that has spread to other parts of the body) or fatal cancer is even lower for people who have a healthy weight and are consuming vitamin D. I will.
The results published in the journal Jama Network Open are based on the vitamin D and omega-3 trials (vitals) completed in 2018.
At that time, scientists found that vitamin D did not reduce the overall incidence of cancer, but it did reduce the risk of cancer death.
However, a secondary analysis led by Brigham and Women’s Hospital in Boston, Massachusetts, found that vitamin D reduced the overall risk of advanced cancer by 17% and the body mass index (BMI) by 38% in normal people. Is suggested.
Dr. Paulette Chandler, a primary care physician and epidemiologist at Brigham and Women’s Hospital and one of the authors of the study, said:
“Our findings, especially the strong risk reduction seen in people of normal weight, provide new information about the relationship between vitamin D and advanced cancer.”
Over 25,000 people participated in more than five years of vital research.
Participants included men over the age of 50 and women over the age of 55 who had not had cancer at the start of the study.
Subjects were divided into four groups. The first group took vitamin D (2,000 IU / day) daily with omega-3s. The second group took vitamin D and placebo, a substance designed to have no therapeutic value. The third group consumed omega-3s and placebo, while the fourth group had only placebo.
Early results showed no statistical difference in overall cancer incidence, but a reduction in cancer-related deaths was observed.
In a secondary analysis, Dr. Chandler and colleagues assessed the risk of developing advanced cancer among participants who took or did not take vitamin D supplements during the study.
They also investigated whether an individual’s BMI played a role.
Over the next five years, 1,617 of the participants were diagnosed with invasive cancers of the breast, prostate, colorectal, and lungs.
Of those who received vitamin D, 226 were diagnosed with advanced cancer, compared to 274 who received placebo.
Of the people with normal BMI (less than 25) taking vitamin D, 58 were diagnosed with advanced cancer compared to 96 people taking placebo.
The team said no association was found between omega-3 fatty acid supplementation and advanced cancer.
Researchers believe that obesity and the associated inflammation can reduce the effectiveness of vitamin D.
Dr. Chandler said: “Our findings, along with the results of previous studies, support the continued assessment of vitamin D supplementation to prevent metastatic cancer. This is a biologically plausible relationship.
“We need additional research to focus on cancer patients and investigate the role of BMI.”
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