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Air Pollution Increases Women’s Risk of Alzheimer’s Disease, USC Findings – NBC Los Angeles

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Elderly women living in areas with high levels of air pollution may have more brain contractions, such as Alzheimer’s disease, than women living in clean air, according to a study released Wednesday by USC researchers. ..

“For the past few years, the clinical neurology community has recognized late-life exposure to microparticles as an environmental risk factor for dementia, including Alzheimer’s disease, but air pollution alters various brain structures and personal perceptions. Whether it may increase the risk of dementia is still under investigation, “said Diana Yunan, lead author of the study.

“In our study, women in their 70s and 80s who were exposed to high levels of PM2.5 (fine particle contamination) outdoors could have patterns of cerebral atrophy that increased their risk of Alzheimer’s disease over a 5-year period. It turned out to be highly sexual, “said Younan, a senior researcher in the preventive medicine department at Keck School of Medicine at USC.

The study, published online in Neurology, enrolled 712 women with an average age of 78 years who did not have dementia at the start of the study. They had an MRI brain scan at the beginning of the study and then again five years later.

Researchers have found that for every 3 micrograms of air pollution exposure level, the brain contraction score increases by 0.03 points. This could increase the risk of Alzheimer’s disease by 24% over 5 years.

The findings suggest that tightening air quality standards can reduce the risk of dementia in the elderly, the researchers said.

Researchers also found that women were exposed to the highest levels of particulate contamination, as well as women’s brain contractions that were exposed to levels below what the Environmental Protection Agency considers safe, so the findings were “ It has a significant impact on public health, “Younan said.

“Further research is needed, but federal efforts to tighten air pollution exposure standards in the future may help reduce the risk of Alzheimer’s disease in our elderly,” Younan added. I did.

According to the research team, the study only covers the brains of older women, so the results may not be the same for men and young women.

Presidential election Joe Biden has promised to help healthcare professionals fight the crisis on Wednesday, but is still blocked from receiving important migration data. COVID-19 bailout is stalled in Congress.

Along with Younan, the authors of this study are all USC Xinhui Wang, Andrew J. Petkus, Margaret Gatz, Helena C. Chui, and Jiu-Chiuan Chen. Ramon Casanova, Ryan Barnard, Sarah A. Gaussoin, Santiago Saldana, Daniel P. Beavers, Bonnie C. Sachs, Mark A. Espeland, Sally A. Shumaker, Stephen R. Rapp, Wake Forest Medical School. Mark L. Sale and William Bizete of the University of North Carolina. Susan M. Resnick of the National Institute on Aging. Joan E. Manson and Joel A. Salinas of Harvard Medical School. Victor W. Henderson of Stanford University.

This study was supported by grants from the National Institute on Aging and the Southern California Center for Environmental Health Sciences.

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