These are the stories of the British coronavirus that you need to know today.
Oxford vaccine “encouragement” immune response
The Oxford / AstraZeneca vaccine evoked a “promising” immune response, according to Phase 2 data on 560 healthy adults published in. The lancet. It was also safe and well tolerated. The research team reported.
Professor Andrew Pollard, the lead author of the study, commented: It has been tested in this group, which is also the priority group for immunity. “
“This is an ongoing study, but early results are promising,” commented Professor Deborah Dan Walters, chair of the British Society for Immunology COVID-19 and the Immunology Task Force and professor of immunology at Sally University. A vaccine is coming. It is well tolerated in all age groups and reports that older people have fewer side effects. One month after two doses of the vaccine, it is the same in all age groups. Levels of antibody response were seen. There are some age-related differences in cellular immune responses. There were records that needed further investigation, but were recorded during Phase 2 of this study. Positive results are expected from Phase 3 trials if immunological measurements correlate with protection from SARS-CoV-2. “
Meanwhile, MHRA responded to Pfizer’s further “promising” data on vaccines published yesterday.
“We look forward to receiving the full results of the trial as soon as possible, and then rigorously assess the evidence of vaccine safety and efficacy,” said Dr. June Rays, CEO of MHRA. Said in.
T cell data
The results of an EDSAB-HOME study of 2800 people using the Lateral Flow Antibody Home Finger Prick Blood Test Kit also generated data on T cells. “Approximately a quarter of the key worker population surveyed had high levels of T cells that recognize SARS-CoV2 in the blood when they participated in the survey in June 2020,” said the latest. Preprint Said.
“But about half of those who have high levels of T cells in their blood did not have COVID-19, as far as we know-probably earlier due to coronaviruses other than SARS-CoV-2. The cells were there because of the infection.
“Importantly, in our study, people with high levels of circulating T cells appeared to be protected from COVID-19 four months after recruitment in June 2020. This was previously. Who did not get infected with COVID-19? “
Dr Rupert Beale of the Francis Crick Institute commented through the Science Media Center: “About a quarter had highly responsive T cells, and more than half had serological evidence of previous infections using tests with a sensitivity of about 70%. A very small percentage of adults ( Less than 10%, perhaps less than 10%) is protected by existing T cell immunity. “
Test and trace
England’s national testing and tracing system is still missing 39.5% of all identified contacts. Latest data Performance.
Downing Street has issued a statement acknowledging that there is still room for improvement.
The community health protection team reached 98.9% of the identified close contacts.
We
National Bureau of Statistics COVID-19 was the third leading cause of death in England and Wales, according to October data.
The age-standardized mortality ratio for COVID-19 deaths was 63.5 per 100,000 in England and 81.9 per 100,000 in Wales.
Today’s Daily data An additional 22,915 UK positive tests were reported, killing 501 people.
The hospital has 16,409 COVID-19 patients and uses 1430 ventilator beds.
Today, Dr. Hans Kruge, WHO’s Director of Europe, said that COVID-19 now kills one person every 17 seconds in Europe.
Care home test
UCL’s Vivaldi2 study of COVID-19 infections in UK care facilities has been expanded to check 14,000 residents and staff quarterly.
This study assesses how antibodies to the virus and cell-mediated immunity differ between groups and provides information for future policy making.
Dr. Laura Shallcross of the UCL Institute of Health Informatics said: Help protect the most vulnerable members of society from this catastrophic infection. “
Arthritis drug
international REMAP-CAP A study led by Imperial College London and the National Center for Intensive Care Audit and Research (ICNARC) in the United Kingdom reported improved outcomes in patients with severe COVID-19. Tocilizumab..
In a news release, Imperial said unpublished study data from 303 randomized patients gave an estimated odds ratio of 1.87 for better results with tocilizumab compared to no immunomodulation.
Professor Anthony Gordon of Imperial commented: “These early findings show that treatment with this immunomodulatory drug is effective in patients with severe COVID-19 in the intensive care unit. Once results are available from all participants, our findings Hope to be clear. Guidance to clinicians to improve outcomes for the most ill COVID-19 patients. “
BAME patients with severe kidney disease
Afro Caribbeans with end-stage renal disease (ESKD) are more likely to be hospitalized with COVID-19 than other ethnic groups, according to a study by King’s College London. Nephrology I found.
Lead author Dr. Antonella Corsillo said in a news release: “Patients with ESK D are at high risk of severe COVID-19 and often have a poor prognosis. Due to the very severe COVID-19, the mortality rate of hospitalized patients is 36%, which is international and others. Similar to a recent study in. We observed a disproportionately high prevalence of inpatient Afro-Caribbean people, and low blood glucose levels (hypoglycemia) were common during hospitalization in this high-risk population. And that adjustment was seen. Diabetes treatment was frequently needed. “
Politician “Science Suppression”
According to the article, politicians and governments are suppressing science, and people die when good science is suppressed. BMJ, Univadis From Medscape report.
Dr. Kamran Abbasi, Editor-in-Chief of the BMJ, said in the editors: Government appointees can ignore science or cherry-pick-another form of misuse-and indulge in anti-competitive practices in favor of their own products and the products of friends and associates. I can do it.
“As powerful people become more successful, richer, and more intoxicated, the inconvenient truth of science is suppressed. When good science is suppressed, people die,” he writes.
Christmas clarification
Dr. Susan Hopkins of the UK Public Health Services yesterday answered a question about the Christmas blockade at a briefing on Downing Street. She suggested that for each day of the relaxed limit, the two-day limit would need to continue.
PHE has now clarified this by saying she “miss pork” Sage Expert modeling shows that a daily limit of 5 days of relaxation is required.
Consultant twins born while she was in a coma
Perpetual Uke, a rheumatism consultant at Birmingham City Hospital, took her twin babies home while she was in an induced coma.
She became ill in March 24-25 weeks gestation and was COVID-19 positive. The twins gave birth by Caesarean section.
Mrs. Uke said Sky News: “I was pregnant at that stage in 24 to 25 weeks, but by the time I woke up I was very confused. I thought I had lost my pregnancy because I couldn’t see the bumps. I was really worried.
“Sometimes I see them in tears, I never thought they would accomplish it. It’s amazing that the science of medical professionals can offer.”
Hospital consultant Perpetual Uke was in a coronavirus-induced coma as her twins were delivered by caesarean section.
Read more here: https://t.co/CJf3fe152W pic.twitter.com/Imv6b8QcPv
— SkyNews (@SkyNews) November 19, 2020
See more Medscape Global Coronavirus Updates Coronavirus Resource Center.
