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Rheumatoid Arthritis Drugs Seem to Help Covid Patients in ICU | World News
Drugs used to treat rheumatoid arthritis appear to help patients in the intensive care unit with the most severe coronavirus infections, the researchers say.
Tocilizumab, an anti-inflammatory drug, has improved outcomes in critically ill patients, according to early results in an international study investigating whether the drug and others improve survival and reduce the time patients spend on intensive care.
The findings have not been published in peer reviews or journals, but the drug is the second most effective for the most ill Covid patients, following positive steroids, if confirmed by more study data. It will be a cure. Dexametazone Earlier this year.
Professor Anthony Gordon of Imperial College London, UK Principal Investigator for the REMAP-CAP exam, said: “If all data are reviewed by the guidelines group and drug regulators, it could be standard treatment.”
The study recruited more than 2,000 Covid patients in 15 countries to evaluate the potential benefits of tocilizumab and other immune system regulators such as tocilizumab, anakinra, and interferon.
Scientists in this study analyzed the first 303 patients who were treated with tocilizumab or other or randomized to not receive immunomodulators, after the patients who received the drug showed improvement. , Announced early results. However, the nature of the improvement is unclear, as scientists have not yet figured out whether the drug increased survival, reduced time in the intensive care unit, or both.
Previous trials of tocilizumab in patients with coronavirus reported a variety of results. One major trial Of the moderately ill Covid patients announced last month, the drug was found to have no difference in mortality or likelihood of patients requiring intubation.
Stephen Evans, a professor of pharmacoepidemiology at the London School of Economics and Tropical Medicine, said the results need to be “carefully treated” at this early stage.
“Combining data from all reported trials may suggest that Covid-19 has the benefit of taking tocilizumab in severe cases, but it may not be significant,” he said. Said. Controlling inflammation may help because some critically ill patients die of the overwhelming inflammation caused by the severe pneumonia caused by the virus.
“In Covid, different drugs may work most effectively at different times of the disease. Remdesivir may work well in the early stages of the disease and does not seem to work in the later stages, Dexamethasone seems to work well in the late stages of the disease, not in the early stages, “he added.
Dexamethasone, which costs about £ 5 per dose, was found in a study that reduced the risk of death for patients on mechanical ventilation by a third. It is currently part of the standard treatment for Covid patients in hospital.
The cost of tocilizumab is between £ 500 and £ 1000, depending on whether the patient is given one or two doses. “Compared to dexamethasone, it’s more expensive. It’s still relatively cheap compared to the cost of staying in an intensive care room, which can reach thousands of pounds daily,” Gordon said.
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