Health
Arthritic drugs give hope to critically ill Covid patients
Scientists have found that the drugs used to combat rheumatoid arthritis significantly improve the outcome of patients with severe Covid-19. This is the latest breakthrough in the search for potential therapies.
The immunosuppressant tocilizumab has been found to be very effective in randomized controlled trials of 303 patients, so researchers should stop hiring people in the “untreated group.” I was told.
This was the first immunomodulatory drug found to affect outcomes in hospitalized Covid-19 patients. Cheap and abundant steroid dexamethasone, And the antiviral drug remdesivir.
However, after clinical trials, the World Health Organization concluded last month that remdesivir had no substantial effect on the patient’s viability, and the European Society of Intensive Care Medicine is now to treat Covid in hospital. We recommend that you should not use this medicine on a daily basis. 19 patients.
Scientists have pointed out that the evidence for tocilizumab has been inconsistent, but hopes it can be added to the arsenal of treatments used to improve outcomes in the most critically ill patients.
“These are very exciting results and very encouraging,” said Professor Anthony Gordon, Chair of Anesthesia and Principal Investigator of Research at Imperial College London. “Every drug is unlikely to work on its own, so you need to find the right combination of treatments.”
Scientists were measuring both mortality and the length of time spent in the intensive care unit. They found that there was a 99.75% chance that the drug would improve outcomes in the most severely ill patients, but since we have not fully analyzed the data, it is exactly which of these outcomes improved. Unknown. They hope to complete the analysis in the coming weeks.
The results of the Remap-Cap study conducted by researchers at Imperial College London and Utrecht University in the Netherlands were inconsistent with a randomized controlled trial of tocilizumab conducted by researchers in the United States. No merit In preventing intubation or death.
Imperial researchers believe that the results they observe stem from the fact that they saw patients, especially those with severe illness, and intervened very early in the exacerbations of these patients.
“Results need to be treated with caution at this early stage,” said Stephen Evans, a professor of pharmacoepidemiology at the London School of Economics and Tropical Medicine.
“During Covid’s illness, different drugs may work best at different times,” he said, and it is not yet clear whether dexamethasone or tocilizumab will provide greater benefits. ..
Tocilizumab targets a single immune signaling molecule called a cytokine and, unlike common steroids such as dexamethasone, is not commonly used in intensive care units.
Professor Gordon said that immunosuppressive drugs used to treat arthritis were more expensive than common steroids, but still significantly cheaper than long-term stays in the ICU ward.
In the first wave of the pandemic, he said, Covid-19 patients admitted to the ICU stayed in the ward for an average of 10-12 days.
“This is not the answer in itself, but it is encouraging for scientists to be …. It provides light at the end of the tunnel.”
In total, the Remap-Cap trial enrolled more than 2,000 patients in 15 countries in 260 hospitals worldwide, all randomized to receive different treatment combinations.
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