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Gut-lung axis: changes in gut microbiota and biotransformers may be associated with COPD, studies reveal




You might imagine that your gut health has a major role to play only in your digestive and metabolic health, but the condition of your gut microbiome also affects other aspects of your health. .. Recent studies have established the presence of the cerebrointestinal axis. This suggests that the intestine and brain are linked via biochemical pathways.

Studies have shown that neurological disorders such as Parkinson’s disease are not only associated with the gut flora, but also with other aspects of cognitive health and decline.

However, while the term cerebrointestinal axis is rapidly gaining in popularity, there is also what is called the cerebrointestinal axis, and it should be remembered that the imbalance can have immeasurable effects on your health. It is important.

Studies published in Forefront of cellular and infectious microbiology In February 2020, he explained that the connection between the lung and intestinal flora forms an inconspicuous but complex pathway. In fact, the intestinal-lung axis contains interactions between microorganisms that have invaded the body, apart from the microorganisms in the body.

This suggests that the gut-lung axis plays a much larger role in the formation of an immune response against infections and can interfere with the process of respiratory and gastrointestinal disorders.New research published in Nature Communications This intestinal pulmonary axis suggests that it also functions in patients with chronic obstructive pulmonary disease (COPD).

Intestinal-lung axis in COPD patients

COPD is a series of lung diseases that primarily include chronic bronchitis and emphysema. It is a progressive inflammatory disease without curative treatment and is currently the third leading cause of death in the world.

New studies suggest that the lung microbiome contributes to the progression of COPD, but recent studies have shown that the lung microbiome is essential for COPD, despite reduced bacterial diversity. It is suggested that it does not change to. On the other hand, many COPD patients also suffer from colitis, indicating that the intestinal-lung axis may be working here.

Therefore, researchers hypothesize that changes in the gut environment may contribute to the onset and progression of COPD, and in fact changes in the gut microbiota may be a more reliable indicator of COPD. I set it up.

To assess the validity of this hypothesis, the researchers analyzed stool samples from 28 COPD patients (54% female) and 29 healthy participants (66% female). Next, we compared the gut microbiota and metabolite profiles of both groups. The analysis also considered differences in participants’ age, diet, and smoking habits.

Researchers found that 146 bacterial species differed between COPD and a healthy group of participants. Patients with COPD had elevated levels of certain bacteria, including: Streptococcus sp000187445, Streptococcus vestibularis, And multiple members Lachnospiraceae family. These bacteria are associated with reduced lung function. Scientists have also been able to characterize certain metabolites in stool samples from COPD patients. It shows the composition of 46% lipids, 20% foreign bodies, and 20% amino acid-related metabolites.The presence of Streptococcus parasanginis-B It was also associated with the presence of COPD-related metabolites.

This study shows that not only are the intestinal and fecal microbiomes of COPD patients different from those of healthy individuals, but certain features of fecal metabolites are reliable biomarkers of COPD.

Researchers also have a better understanding of the gut-lung axis, especially how it affects the progression of respiratory disease, in treatments, drugs, and perhaps future treatments. It also suggests that it may provide a suitable means for development.

For more information Chronic obstructive pulmonary disease..

The Firstpost Health article was created by, India’s first and largest resource for validated medical information. At myUpchar, researchers and journalists work with doctors to provide all the information about health.

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