A study from the lab of Dr. Tilmara-Devicaneganti, an Indian-born researcher working at St. Jude Children’s Research Hospital in Tennessee, was published online in the journal Cell and discovered a COVID-related hyperinflammatory immune response. Later identified the drug-19, which triggers tissue damage and multiple organ failure in mice. Inflammatory cell death pathway..
Researchers elaborated on how the inflammatory cell death signaling pathway worked, leading to treatments that could disrupt the process.
“Understanding the pathways and mechanisms that cause this inflammation is important for development. Effective treatment strategy“. Kaneganti, vice chairman of the Faculty of Immunology, St. Jude, said.
Kaneganti was born and raised in Telangana..She got a bachelor’s degree in Kakatiya University I majored in chemistry, zoology and botany in Warangal. After that, she got a master’s degree. He holds a PhD from Osmania University, India. She joined St. Jude Garden in Memphis, Tennessee, USA in 2007.
“This study provides that understanding of certain cytokines that activate the inflammatory cell death pathway and have considerable potential for the treatment of COVID-19 and other highly deadly diseases, including sepsis. I have identified, “she said.
Other researchers were St. Jude’s Shradaturadar, Paris Marsamir, Minchen, Balamrugansundalam, Barajbanos, RK Subbaraomali Reddi, Patrick Schleiner, Jeffrey Neil, Peter Vogel, and Richard Webby. Evan Peter Williams, Lillian Zarduondo, Colleen Beth Johnson, University of Tennessee Health Science Center.
COVID-19 is caused by the SARS-CoV-2 virus. The infection killed more than 1.2 million people and made millions more ill in less than a year.
Infections are characterized by elevated blood levels of multiple cytokines. These small proteins are primarily secreted by immune cells and ensure a rapid response to limit the virus. Some cytokines also cause inflammation.
Phrase Cytokine storm St. Jude has also been observed in statements in inflammatory diseases such as COVID-19, sepsis, and hemophagocytic lymphohistiocytosis (HLH), with dramatic increases in blood cytokine levels and other It is used to explain immune changes.
However, the specific pathways that cause cytokine storms and subsequent inflammation, lung damage, and organ failure in COVID-19 and other disorders are unknown.
It also lacked the cellular and molecular mechanisms that comprehensively define cytokine storms. Kanneganti’s team focused on a selected set of the most elevated cytokines in COVID-19 patients. Scientists have shown that a single cytokine did not induce cell death in innate immune cells, it said.
“The results of this study correlate TNF-α and IFN-γ-induced inflammatory cell death with COVID-19,” said Kannganti.
“This result also shows that therapies targeting this combination of cytokines are not only for COVID-19, but also for the treatment of several other often fatal disorders associated with cytokine storms in rapid clinical trials. It suggests that it is a candidate, “she said.
“I was excited to connect these points to understand how TNF-α and IFN-γ cause PANoptosis,” said co-lead author Rajendra Karki, a scientist at the Kannganti Institute. Stated.
“Certainly, understanding how PANoptosis contributes to disease and mortality is important for identifying treatments,” said co-lead author Bhesh Raj Sharma, a scientist at the Kanneganti Institute. Added.
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