According to a new study, Bacillus Calmette-Guerin (BCG), one of the oldest vaccines for tuberculosis, is associated with a reduced chance of being infected with the Covid-19 virus.
As part of a study published in The Journal Of Clinical Investigation, researchers found evidence of antibodies to SARS-CoV-2, the virus that causes Covid-19, in more than 6,000 healthcare professionals at the Cedars-Sinai Health System. I tested the blood. And I asked them about their medical history and vaccination history.
They found that previously BCG-vaccinated workers (about 30% of those surveyed) were significantly less likely to test positive for SARS-CoV-2 antibodies in their blood, or coronavirus. Or I found that I was unlikely to report that I was infected with the coronavirus. -There are more related symptoms in the last 6 months than those who have not.
These effects were independent of whether workers were vaccinated against Neisseria meningitidis, Streptococcus pneumoniae, or influenza.
According to Moshe Arditi, co-author of the study, it was not clear why SARS-CoV-2 antibody levels were low in the BCG group.
“Individuals vaccinated with BCG may have less illness and therefore less production of anti-SARS-CoV-2 antibodies or have shown a more efficient cellular immune response to the virus,” said the director. One Alditi Medical Doctor said. Professor of Pediatrics and Infectious Diseases and Immunology and Pediatrics and Biomedicine at Cedars Sinai.
“BCG vaccines have long been known to have general preventative effects against a variety of non-tuberculosis bacterial and viral diseases, such as neonatal sepsis and respiratory infections, so I am interested in research. It would be great to have one of the oldest vaccines. It could help defeat the newest pandemic in the world. “
In a new study, low antibody levels in the BCG group persisted despite the fact that these individuals had a high frequency of hypertension, diabetes, cardiovascular disease, and COPD. These are known risk factors that make people more susceptible to SARS-CoV-. 2 And develops a more severe form of Covid-19 disease.
Arditi does not believe that BCG is more effective than certain vaccines against Covid-19, but it is approved more quickly due to its strong safety profile proven by years of use. , Explained that it may be available.
“This is a potentially important bridge that could bring some benefits until the most effective and safe Covid-19 vaccine becomes widely available,” he said.
In the United States, the FDA-approved BCG vaccine is used as a treatment for bladder cancer and for people at high risk of developing tuberculosis (TB).
“Based on our findings, we believe that large-scale randomized clinical trials are urgently needed to see if BCG vaccination can induce a protective effect against SARS-CoV2 infection.” And a public health study at the Smithart Institute in Cedars Sinai, an associate professor of cardiology.
Several randomized clinical trials have been initiated to study the potential protective effect of BCG vaccination against Covid-19.
Cedars Sinai, along with the University of Texas A & M, Baylor College of Medicine, and the University of Texas MD Anderson Cancer Center, is the site of the US division of this ongoing trial that is recruiting hundreds of healthcare professionals.
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