Health
“Hidden” prostate cancer usually means good results
By Robert Preidt
Health Day Reporter
Monday, November 23, 2020 (HealthDay News)-Negative biopsies of patients with early-stage prostate cancer who choose to actively monitor are associated with a lower risk of disease progression, but the cancer has progressed completely. It doesn’t show that it’s gone, new research shows.
Active monitoring refers to close monitoring of signs of cancer progression. This is often referred to as “careful follow-up.” Patients may undergo regular prostate-specific antigen (PSA) tests, prostate tests, diagnostic imaging, and repeated biopsies.
The purpose of active monitoring is to avoid or delay treatment and its side effects without putting the patient at risk of cancer progression and death.
From time to time, actively monitored patients have negative biopsies that show no evidence of prostate cancer. Some of these patients may believe that their cancer has “disappeared,” but according to the authors of a recently published study, prostate cancer was not detected in biopsy samples. There is likely to be a small amount of or a limited amount of hidden area. Urology Journal..
“Negative biopsies are good news, but the long-term effects associated with such” hidden “cancers remain unclear,” said Dr. Carissa Chu, a research author at the University of California, San Francisco.
For this study, Chu et al. Analyzed data from 514 men who underwent active surveillance of early-stage prostate cancer between 2000 and 2019. All of them underwent at least three surveillance biopsies after their first prostate cancer diagnosis. The median follow-up was nearly 10 years.
According to the report, 37% of these patients had at least one negative biopsy, of which 15% had consecutive negative biopsies.
Men with a negative biopsy showed more favorable disease characteristics, such as lower PSA density and fewer cancer samples on the first prostate biopsy. Negative biopsies were also associated with good long-term outcomes, the researchers said.
After 10 years, the survival rate without treatment for prostate cancer (surgery, radiation, etc.) was 84% for men with consecutive negative biopsies, 74% for men with one negative biopsy, and biopsy. Was 66% of non-negative men.
After adjusting for other factors, the researchers concluded that men who had one or more negative biopsies were much less likely to have cancer detected in later biopsies.
“For men under active surveillance, a negative biopsy indicates a low dose of the disease and a low rate of disease progression,” Chu said in a journal news release. I will. “These” hidden “cancers have excellent long-term outcomes and are ideal for continuous active monitoring. “
For more information
For prostate cancer National Cancer Institute..
Source: Urology Journal, News Release, November 17, 2020
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