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Regulation of intestinal hormones for abnormal fat production in obesity and fatty liver disease

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Study: Regulation of intestinal hormones in abnormal fat production in obesity and fatty liver disease

According to a study led by Professor Johnsk Kim Kemper of Illinois, the intestine releases hormones hours after eating, stopping fat accumulation in the liver, but obesity and fatty liver disease cause dysregulation of the process. It has become. Credit: L. Brian Staffer

Intestinal hormones play an important role in regulating fat production in the body. Researchers at the University of Illinois at Urbana Champaign say that one of the key hormones released hours after a meal stops fat production by regulating gene expression in the liver, but is abnormal in obesity. Discovered in a new study.

The study, led by Professor Jongsook Kim Kemper, a professor of molecular and integrated physiology, and research scientist Young-Chae Kim, was published in a journal. Nature Communications..

After eating, the pancreas produces insulin, triggering the liver to convert digested food into fat and store it in a process known as lipogenesis.After a few hours, when the body begins to transition to fasting mode, the liver slows down .. Although the insulin pathway has been thoroughly studied, little is known about the pathway by which lipid production is turned off, Kemper said.

In a new study, Kemper’s team found that the mouse intestinal hormone FGF15 and its human corresponding FGF19 turn off liver fat-producing genes. Hormones are released hours after eating when the body transitions from eating to fasting. FGF15 / 19 activates regulatory molecules to enter and inhibit the nucleus, the center of cells where DNA is stored. ..

“This intestinal hormone actually acts as a breaker for insulin action and is tightly regulated because it specifically inhibits lipid production in the liver,” Kemper said. “For example, as the holidays approach, eating cookies causes the body to release insulin and promote lipid production. If lipid production does not decrease later when the body becomes fasted, excess fat will be in the liver. The FGF19 hormone puts a brake on lipogenesis because it accumulates in. “

In addition, in experiments involving obese mice, In the case of non-alcoholic fatty liver disease, researchers have found that the pathway to stop fat production is dysregulated.The genes regulated by intestinal hormones were very active and FGF15 / 19 was activated. It did not invade the nucleus of the cell and no suppressor markers were added to the gene.

“This study can be very important for understanding this pathway and investigating how it is abnormal in obesity and non-alcoholic fats. “We have a better understanding of the disease,” Kemper said. And other metabolic disorders. It can also affect other illnesses, such as diabetes, where obesity is a risk factor, and certain cancers.

“Based on this study, we may be able to find treatment options to target this pathway and enhance accommodation.”


Researchers Discover a Molecular Link Between Liver Disease, Insulin Resistance


For more information:
Young-Chae Kim et al, Intestinal FGF15 / 19, physiologically suppress hepatic lipid production in late feeding by activating SHP and DNMT3A. Nature Communications (2020). DOI: 10.1038 / s41467-020-19803-9

Quote: Study: Regulation of intestinal hormones of abnormal fat production in obesity, fatty liver disease (2020, November 24) from https://medicalxpress.com/news/2020-11-gut-hormones-fat-production- Abnormal .html acquired on November 24, 2020

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