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Research Questions Plasma as COVID Treatment

 


Arnie Mandel

Health Day Reporter

Wednesday, November 25, 2020 (HealthDay News)-Early COVID-19 PandemicThe case report suggested that injecting plasma from people who survived the disease into highly ill patients may help boost results.

However, the findings released on November 24 New England Journal of Medicine, Along with disappointing results from previous trials, suggests that their first hope may be unfounded.

The new study was carried out by Argentine researchers. We compared the outcomes of 228 inpatient COVID-19 patients who received so-called “convalescent plasma” and 105 patients who did not.placebo group”).I was sick enough to develop everything pneumonia..

However, one month later, “no significant difference was found between the convalescent plasma group and the placebo group” in terms of clinical outcome, according to a team led by Dr. VA Simonovich, about 11% of patients with both. Died in the group. Italian hospital in Buenos Aires.

The theory behind the use of survivors’ blood plasma In people fighting COVID-19, plasma Immune system An agent who may help the recipient in the fight against illness.

However, previous studies from India (this time in patients with “moderate” COVID-19) also had little therapeutic benefit in preventing the disease from progressing to more severe stages. ..The study was led by Dr. Anup Agarwal of the Indian Medical Research Council in New Delhi on October 22nd. BMJ..

According to a US expert unrelated to either trial, it may be time to give up convalescent plasma as a viable COVID-19 treatment.

“There were several major trials that showed the same results. Convalescent plasma does not appear to affect the course of COVID-19,” said Dr. Mangala Narasimhan. She is Senior Vice President and Director of Critical Care Services at Northwell Health in New Hyde Park, NY.

Narasimhan also said in an Argentine trial, “Even if you properly measure the amount of antibody they were giving people. [in the transfusions], No merit was seen. “

She believes that other treatments should continue to be the first-line choice for severe COVID-19.

“new Monoclonal antibody If a COVID-19 patient is given a more targeted and reliable antibody load and given early after a positive test, it can affect the course of the disease, “Narasimhan said.

For more information

For more information on how to treat coronavirus at home Centers for Disease Control and Prevention..

Source: New England Journal of Medicine, November 24, 2020; Mangala Narasimhan, DO, SVP, Director of Critical Care Services, Northwell Health, New Hyde Park, NY

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