New CAR T cells Therapies developed by UCL researchers and designed to target cancerous tumors show promising early results in children with neuroblastoma, a rare form of childhood cancer.
For this principle empirical study, researchers at UCL Great Ormond Street Child Health Institute (GOS ICH) and UCL Cancer Institute have modified, recognized, and killed patients’ own T cells (a type of immune cell). I made it possible. Neuroblastoma Tumor cells.
Twelve children with relapsed or refractory (disease does not respond to treatment) neuroblastoma were treated as part of a Phase I clinical trial funded by Cancer Research UK.
Research published in Scientific translation medicineIs one of the first studies to demonstrate CAR T cells that achieve rapid regression against solid tumors (non-hematological cancers). Although the beneficial effects lasted only for a short period of time, this study provides important evidence that this particular CART cell therapy can be used as a future treatment for children with solid tumors.
Neuroblastoma is a rare type of cancer that mainly affects infants and young children and arises from specialized nerve cells (neuroblastomas) that are left out of the baby’s development in the womb.
Up to 100 children are diagnosed with neuroblastoma each year in the UK. Current treatments for children with advanced type neuroblastoma include surgical resection, chemotherapy with stem cell transplantation, radiation therapy, and antibody therapy. Despite this intensive treatment, long-term survival is 50-60 percent.
In CAR T cell therapy, a type of immunotherapy, T cells are designed to contain a molecule called a chimeric antigen receptor (CAR) that can specifically recognize cancer cells.
In this study, patients’ own T cells were modified with CAR to target GD2 surface proteins, which are very abundant in almost all neuroblastoma cells but found at very low levels in healthy cells. did.
Researchers have found that with a sufficient amount of modified CAR T cells, this treatment rapidly reduces the tumor size in some treated patients. These effects were temporary. Importantly, in all patients, CAR T cells did not cause harmful side effects on healthy tissues expressing the GD2 molecule.
Dr. Karin Straathof, a research group leader at UCL GOS ICH and a pediatric oncologist at the Great Ormond Street Hospital NHS Trust, said: “This study shows the antitumor activity induced by these modified T cells.
“Although the antitumor activity seen was transient, it provides an important proof of principle that CAR T cells directed to the GD2 molecule can be used for solid tumors in children.
“High-risk neuroblastoma requires new treatments, and more research hopes to develop them into treatments that provide a more lasting response and increase the number of patients who can be cured. . “
Targeting solid tumors by CAR T cells depends on their infiltration and spread within the tumor microenvironment, and therefore far fewer clinical responses have been reported.
Rapid regression of neuroblastoma cells is promising, especially as this activity was observed in the absence of neurotoxicity that occurs with antibody-based approaches that target GD2. “
Dr. Martin Pule, Senior Author of UCL Cancer Institute
“Targeting neuroblastoma with GD2 CAR T cells seems to be an effective and safe strategy, but further modifications are needed to extend the lifespan of CAR T cells,” Dr. Pule added.
Dr. Sue Brook, Medical Advisor at Cancer Research UK, said: “Children who have difficulty treating cancer, such as neuroblastoma, have limited treatment options, especially if the cancer has recurred.
“The initial results of GD2CAR-T treatment look promising, especially with early safety data, but more work is needed to prolong the response and look forward to the next step in its development. I am. “
The research team is working with Autolus, a clinical biopharmacy company developing next-generation programmed T cell therapies for cancer treatment, to prepare for the next clinical study. This study evaluates AUTO6NG built on this approach, which utilizes the same GD2CAR and additional programming modules designed to extend. Effectiveness And persistence.
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
- Hospitals in Half of US States Near Capacity as Omicron Continues to Scale | American News January 15, 2022
- Krafton sues Google, YouTube and Apple for alleged PUBG clones January 15, 2022
- Garbage and recyclables are piling up as omicron takes its toll on sanitation workers : Coronavirus updates : NPR January 15, 2022
- Netflix gives green light to ‘Drive to Survive’ team tennis documentary January 15, 2022
- Target fashion finds that appear to be from Zara January 15, 2022