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Mice studies reveal the positive effects of drugs that can help roll back age-related mental decline


The elixir’s quest for life may escape us in the human world, but scientists have created the first drugs that they reverse age-related symptoms such as human amnesia and dementia. I believe it may be.

The drug is effective in reconstructing the system that produces protein in cells in the brain after stress-related reactions reduce cell activity. Report by Daily Mail Said.

Researchers at the University of California, San Francisco (UCSF) have tested the drug in aged mice and found that the product is effective in regaining memory and improving the condition of the brain and immune cells. Scientists believe the study showed ways to treat the effects of age on the brain and control symptoms.

A group of researchers have previously studied the effects of the integrated stress response (ISR) felt intracellularly due to certain conditions that affect protein production, such as viral infections and gene mutations that promote cancer. The ISR then stops the cell from producing its protein, allowing it to get rid of the affected cell.

The drug in this case responded in this way, called ISRIB (ISR InhiBitor), and was created in the laboratory seven years ago. Scientists continuing to research the drug have found that it can restore normal brain function almost overnight.

Dr. Susanna Rossi, in the Department of Neurosurgery and Physical Therapy and Rehabilitation Sciences at UCSF, reportedly called this a hasty version of the reversal of cognitive decline.

Results of new research published in Journal eLifeExplained the steps scientists took to reach a conclusion. They used a third batch of three classified mice, young mice, old mice that took the drug for three days, and old mice that did not receive the drug. Mice were trained to escape the water maze by looking for hidden passages. They found that older mice given the drug could then come out much easier compared to others.

Researchers retested mice after 3 weeks to test drug lifespan, and mice treated with the ISRIB drug were superior to older mice and as good as younger mice.

After studying the effects of drugs on the brain, scientists found that drugs help increase electrical activity between neurons and cells, forming better connections with their counterparts. .. Scientists believe this can pave the way for better treatment of dementia, Alzheimer’s disease, Parkinson’s disease, and even amyotrophic lateral sclerosis (ALS).


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