Health
Studies suggest patients receiving low-dose steroids at high risk of cardiovascular disease
Glucocorticoids are widely prescribed steroids to treat a range of immune-mediated inflammatory diseases.High doses of steroids are known to increase risk Cardiovascular disease, The effect of low doses is unknown.
One study suggests that even low doses of glucocorticoids may increase the risk of cardiovascular disease. A study led by Mar Pujades-Rodriguez and colleagues at the University of Leeds was published in PLOS Medicine. To quantify the dose-dependent cardiovascular risk of glucocorticoids, researchers analyzed the medical records of 87,794 patients diagnosed with six different immune-mediated inflammatory diseases treated by 389 in the United Kingdom. did. Primary care clinic from 1998 to 2017.
Researchers found that patients taking less than 5 milligrams of prednisolone per day had almost twice the absolute risk of cardiovascular disease compared to patients not taking glucocorticoids. (Hazard ratio = 1.74; 95% confidence interval 1.64-1.84). All measured CVDs showed a dose-dependent increase in risk ratio, including atrial fibrillation, heart failure, acute myocardial infarction, peripheral arterial disease, cerebrovascular disease, and abdominal aortic aneurysm.
Previously, it was believed that long-term use of 5 mg of glucocorticoid was safe, but this study found that even patients taking low doses were at risk of developing cardiovascular disease. It suggests that it is double.
These findings indicate that patients in need of long-term steroid treatment should be prescribed the lowest effective dose and should have a personalized cardiovascular risk prevention plan that explains past and present steroid use. It suggests that.
This study may have reduced the size of dose-response estimates, limited by the lack of available hospital data on prescription drug compliance, but the authors found that large sample sizes contributed to generalization of the results. thinking about.
According to the authors, “Our findings emphasize the importance of implementing and assessing targeted, intensive cardiovascular risk factor modification interventions, even when prescribing low prednisolone equivalents. Beyond the diagnosis of inflammatory arthropathy and systemic lupus erythematosus, the patient’s cardiovascular risk is monitored promptly and regularly. “
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