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Oral antivirals successfully block SARS-CoV-2 infection — precision vaccination

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Georgia (Precision vaccination)

A new study found that treatment of SARS-CoV-2 infection with the new antiviral drug MK-4482 / EIDD-2801 or Mornupyrabir completely suppressed the virus infection within 24 hours.

Researchers at Georgia State University’s Institute of Biomedical Sciences, led by Dr. Richard Plumper, a prominent university professor at Georgia State University, initially discovered that the drug was potent against the flu virus.

“This is the first demonstration of an oral drug that blocks quickly. SARS-CoV-2 Send “. Dr. Plemper said in a press statement issued on December 3, 2020.

“”MK-4482 / EIDD-2801 It may change the game. “

The drug is currently undergoing Phase 2a / 3 clinical trials sponsored by Ridgeback Biotherapeutics, LP.

Because the drug can be taken orally, treatment can be started early and potentially triple the benefits. That is, it slows the patient’s progression to serious illness, shortens the stage of infection, prolongs patient isolation, and mitigates the emotional and socio-economic sacrifice of rapid local silence. The outbreak was described by these researchers.

“MK-4482 / EIDD-2801 exhibits broad spectrum activity against respiratory RNA virus, and oral administration of infected animals with drugs reduces the amount of virus particles released by several orders of magnitude, dramatically reducing infection. We pointed out early on that it would decrease. ”Added Plemper.

In a study published in Nature microbiology On December 3, 2020, Plemper’s team reused MK-4482 / EIDD-2801 for SARS-CoV-2 and used a ferret model to test the effectiveness of drugs that block the spread of the virus. Did.

“We consider ferrets to be a related model of infection because they easily spread SARS-CoV-2, but most ferrets develop a severe disease that closely resembles SARS-CoV-2, which spreads to young adults. I don’t, “says postdoctoral fellow Dr. Robert Cox. Co-author of research with the Plemper group.

In this study, researchers infected ferrets with SARS-CoV-2 and began treatment with MK-4482 / EIDD-2801 when animals began releasing coronavirus through the nose.

“When infected animals were treated in the same cage with untreated contact ferrets, none of the contacts were infected,” commented Josef Wolf, PhD student and co-lead author of the study at Plemper Labs.

By comparison, all contacts of placebo-treated source ferrets were infected.

If these ferret-based data are translated into humans, these researchers conclude that drug-treated COVID-19 patients may become non-communicable within 24 hours of starting treatment. It was.

Co-authors of this study include RM Cox, JD Wolf, and RK Plemper from Georgia State University. This study was funded by a Public Health Services Grant from the National Institute of Health / National Institute of Allergy and Infectious Diseases to Georgia. No industry conflicts of interest have been disclosed.

EIDD-2801 was invented by Drug Innovations of LLC, Emory, a non-profit biotechnology company wholly owned by Emory University. Since being licensed by Ridgeback, all funding used by Ridgeback for the development of EID D-2801 has been provided by Wayne and Wendy Holman.

In various animal experiments Coronavirus (SARS-CoV-1 and MERS), EIDD-2801, showed improved lung function, reduced weight loss, and reduced viral load in the lungs.

Precision Vaccinations Publish research-based news.

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