Health
According to researchers, the spread of Covid can be slowed down by new antiviral drugs
New Delhi: While the world is fixing hope vaccine To control the covid-19 pandemic, researchers at the Institute of Biomedical Sciences at Georgia State University have found a way to control the spread of the virus. Researchers have found that treating SARS-CoV-2 infection with the new antiviral drug Mornupiravir completely suppresses the virus infection within 24 hours.
Scientists say that blocking widespread community infections of SARS-CoV-2 until mass vaccination is available is paramount to controlling covid-19 and mitigating the catastrophic consequences of a pandemic. I thought it was.
Because the drug can be taken orally, treatment can be started early and potentially triple the benefits. It slows patient progression to serious illness, shortens the stage of infection, mitigates the emotional and socio-economic sacrifices of long-term patient isolation, and quickly silences local outbreaks. Said the scientist.
A group led by Dr. Richard Plumper, a professor at Georgia State University, initially discovered that the drug was potent against the flu virus.
“This is the first demonstration of an orally administrable drug to quickly stop SARS-CoV-2 infection,” Plemper calls the drug a breakthrough.
“Mornupyravir or MK-4482 / EIDD-2801 has broad spectral activity against respiratory RNA virus, and oral administration of infected animals with drugs reduces the amount of virus particles released by several orders of magnitude, resulting in dramatic infection. “We pointed out early on that the virus would decrease,” Plemper said, adding that these properties made MK-4482 / EIDD / 2801 a strong candidate for the pharmacological regulation of covid-19. ..
In a study published in Nature microbiology, Plemper’s team reused MK-4482 / EIDD-2801 for SARS-CoV-2 and used a ferret model to test the effectiveness of the drug in blocking the spread of the virus.
“Ferret is considered a related model of infection because it easily spreads SARS-CoV-2, but most often develops a severe disease similar to SARS-CoV-2 that spreads in young adults. “No,” said Dr. Robert Cox, a postdoctoral fellow. Co-author of research with the Plemper group.
Researchers infected ferrets with SARS-CoV-2 and began treatment with MK-4482 / EIDD-2801 when animals began releasing the virus through their noses.
“When infected animals were treated in the same cage with untreated contact ferrets, none of the contacts were infected,” said Josef Wolf, PhD student and co-author of the study at Plemper Labs. I will. By comparison, all contacts on the source ferret that received the placebo were infected.
If these ferret-based data are converted to humans, drug-treated covid-19 patients may become non-infectious within 24 hours of starting treatment.
MK-4482 / EIDD-2801 is in ongoing Phase II / III clinical trials for SARS-CoV-2 infection.
This study was funded by a Public Health Services Grant from the National Institute of Health / National Institute of Allergy and Infectious Diseases to Georgia.
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