Connect with us

Health

A new form of Alzheimer’s disease found in the cerebrospinal fluid indicates the stage of the disease

Published

on

 


A new form of Alzheimer’s disease in the fluids surrounding the brain and spinal cord, according to a study by researchers at the University of Washington, indicates at what stage of the disease a person is and tracks tau protein tangles in the brain. Of medicine. Tau tangles are thought to be toxic to neurons, and their spread through the brain heralds death of brain tissue and diminished cognitive function. Tangles appear as the early asymptomatic stage of Alzheimer’s disease develops into the symptomatic stage.

The discovery of so-called microtubule junction tau (MTBR tau) in cerebrospinal fluid leads to a way to diagnose people in the early stages of Alzheimer’s disease before symptoms appear or when symptoms are still mild and misdiagnosed. There is a possibility. It may also accelerate efforts to find cures for catastrophic diseases by providing a relatively easy way to measure whether treatment slows or stops the spread of toxic tangles.

This study was published in Brain on December 7th.

“This MTBR tau fluid biomarker can identify the stage of Alzheimer’s disease by measuring the tau that makes up the tangle and showing how much tau lesions are in the brain of patients with Alzheimer’s disease,” said the senior author. Says. Randall J. Bateman, MD, Charles F. and Joan Knight, a prominent professor of neurology. Bateman is treating patients with Alzheimer’s disease on the University of Washington’s medical campus. “If we can translate this into a clinic, there is a way to know if a person’s symptoms are due to the tau pathology of Alzheimer’s disease and where they are in the course of the disease, without having to do a brain scan. Is invaluable in providing information to patient care and in guiding treatment decisions in the future. “

Alzheimer’s disease begins when a protein in the brain called amyloid begins to form spots in the brain. During this amyloid stage, which can last for more than 20 years, people show no signs of cognitive decline. However, shortly after tau tangles began to spread to neurons, people began to show confusion and amnesia, and brain scans showed increased atrophy of brain tissue.

Tau tangles can be detected by positron emission tomography (PET) brain scans, but brain scans are time consuming, costly, and not available everywhere. Bateman and colleagues are developing a diagnostic blood test for Alzheimer’s disease. Amyloid Or another Tau shapeHowever, neither test can determine the amount of tau entanglement throughout the stage of the disease.

MTBR tau is an insoluble portion of tau protein and is the main component of tau tangles. Bateman and his first author, Cantaholly, a visiting scientist in Bateman’s lab, found that certain MTBR tau species are abundant in the brains of people with Alzheimer’s disease and in the cerebrospinal fluid that soaks the brain. I realized that measuring species levels could be a way to measure how toxic tangles are spread throughout the brain. Previous researchers who used antibodies to tau could not detect MTBR tau in cerebrospinal fluid. However, Horie et al. Have developed a new method based on the purification of tau from solution using chemicals followed by mass spectrometry.

Using this technique, Horie, Bateman and colleagues analyzed the cerebrospinal fluid of 100 people in their 70s. Thirty had no cognitive impairment or signs of Alzheimer’s disease. Fifty-eight had amyloid plaques with no cognitive symptoms or mild or moderate Alzheimer’s disease. And 12 had cognitive deficits caused by other conditions. Researchers have found that levels of a particular form (MTBR tau 243) in cerebrospinal fluid are elevated in people with Alzheimer’s disease, which increases as human cognitive impairment and dementia progress. ..

Researchers at Washington University in St. Louis have discovered a new form of Alzheimer’s disease protein tau in the body fluids that surround the brain and spinal cord. This form of tau, known as MTBR tau, indicates the stage of Alzheimer’s disease in a person and tracks tau protein tangles in the brain. (Image: Sarah Moser / School of Medicine)

The researchers validated the results by following 28 members of the original group for 2-9 years. Half of the participants had some degree of Alzheimer’s disease at the beginning of the study. Over time, MTBR tau 243 levels increased significantly in the Alzheimer’s disease group, in step with worsening scores on cognitive function tests.

The gold standard for measuring tau in the living brain is the tau-PET brain scan. The amount of tau seen on a brain scan correlates with cognitive impairment. To see how their technique fits the gold standard, researchers compared the amount of tau seen in 35 brain scans – 20 with Alzheimer’s disease and 15 without – cerebrospinal fluid. Level of MTBR tau 243 in liquid. MTBR tau 243 levels are highly correlated with the amount of tau identified by brain scans, suggesting that their technique accurately measured the amount of tau, or damage, accumulated in the brain.

“Currently, there are no biomarkers that directly reflect the pathology of cerebrospinal fluid or brain tau in the blood,” Horie said. “What we have found here is that as the pathology of tau progresses, a new form of tau, MTBR tau 243, continues to increase. This not only allows us to diagnose Alzheimer’s disease. It may be a way for people to know where they are sick. Also, some specific MTBR tau species have been found in the space between neurons in the brain, which separates them from one neuron. It suggests that it may be involved in the spread of tau entanglement in neurons. The finding suggests a new treatment for Alzheimer’s disease based on targeting MTBR tau and stopping its spread. Open a new window. “

..

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos



Pictures Credit

ExBUlletin

to request, modification Contact us at Here or [email protected]