Health
AstraZeneca COVID vaccine effective in late-stage trials
By Robert Preidt
Health Day Reporter
Tuesday, December 8, 2020 (HealthDay News)-COVID-19 in AstraZeneca vaccine Safe and effective, new data from late trials show.
Overall, vaccine According to a team led by researchers at Oxford University in the United Kingdom, 70% of cases are protected from symptomatological disorders. After half doses, full doses were 90% for study volunteers, compared to 62% for two full doses.
“Our findings are vaccineThe effectiveness of the study exceeds the threshold set by health authorities and can affect public health, “said Andrew Pollard of Oxford, the lead author of the study.
Interim findings are from Phase 3 trials in the UK and Brazil with more than 11,600 participants. Most of them (82%) were between the ages of 18 and 55. This is because older people will be hired later and will be investigated in future data analysis.
With a median of 3.4 months, 3 participants had serious vaccine-related side effects, according to safety data from approximately 24,000 people in four trials in the United Kingdom, Brazil and South Africa. It was only a person. According to the findings published online on December 8, everything has recovered or is recovering and remains in the trial. Lancet..
“The results presented in this report provide important findings from our first interim analysis,” said Melin Boise, a research author at Oxford University, in a news release of the journal. .. “Future analysis will include more data as it becomes available, investigating differences in key subgroups such as older people, different ethnic groups, doses, timing of booster vaccines, and which immune response. Determine if is equivalent to protection from infection and illness. “
Previous Clinical trial One of the vaccines has found that the vaccine provokes an immune response between antibodies and T cells and is safe for people over the age of 18.
Researchers have not yet been able to assess how long the vaccine provides protection. More data needs to be collected to determine the length of time the vaccine is effective and the need for booster shots.
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“Despite the worldwide spread of COVID-19, most of the population in many countries is uninfected and non-immune,” said Sara Gilbert, co-author of the study, also from Oxford. May play an important role in growth ImmunityIn the near future, the use of multiple effective vaccines may be approved to prevent serious illness and mitigate health crises. “
Gilbert added, “For the first time, we have shown that the adenovirus vector vaccine, a type of vaccine technology that has been used since 2009, is effective and can contribute to the disease management of COVID-19. Pandemic.. “
The other two major Coronavirus The Pfizer and Moderna vaccines showed approximately 95% efficacy after two doses in a late study.Both employ new technology for priming using messenger RNA Immune system Attacks a new coronavirus. New data posted on the US Food and Drug Administration website on Tuesday prior to the December 10 meeting of the Vaccine Advisory Board showed that the Pfizer vaccine was 52% effective after a single dose.
For more information
The US Centers for Disease Control and Prevention COVID-19 vaccination..
Source: Lancet, News Release, December 8, 2020
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