Interim analysis confirms the safety of Oxford’s COVID-19 vaccine | Weather Channel-Weather Channel Articles

In significant developments, the first complete results from the interim analysis have an acceptable safety profile for the Oxford COVID-19 vaccine and are effective against symptomatological coronavirus-induced diseases, with 23,745 participants. We confirmed that only three of them were experiencing serious adverse events.

According to the interim results of the Oxford COVID-19 vaccine trial, the vaccine prevented symptomatological disease in 70% of cases, and the vaccine efficacy was 62% in two full doses and 90% in the next half. .. Full dose. This result is the result of the first fully peer-reviewed efficacy published for the COVID-19 vaccine and is published in The Lancet.

The results are based on pre-designated pool analysis of Phase 3 trials in the UK and Brazil (11,636) and safety data from a total of 23,745 participants in four trials in the UK, Brazil and South Africa. I am. All participants have recovered or are recovering and remain on the exam.

“The results presented in this report provide important findings from our first interim analysis,” said Merryn Voysey, a research author and physician at Oxford University. “Future analysis will include more data as it becomes available, investigating differences in key subgroups such as older people, different ethnic groups, doses, timing of booster vaccines, and which immune response. Determines if is equivalent to protection from infection and illness, “the author said.

The Oxford COVID-19 vaccine uses a chimpanzee adenovirus viral vector that cannot cause disease in humans and expresses the SARS-CoV-2 spike protein. This means that the vaccine delivers the genetic code of the spiked protein to the cells of vaccinated people, which produces the protein and teaches the immune system to recognize and attack the virus.

Studies have shown that vaccines elicit an immune response between antibodies and T cells and are safe for adults over the age of 18 (including the elderly), according to previous study results. “Our findings show that the effectiveness of our vaccine exceeds the threshold set by health authorities and may have potential public health implications,” the study said. Said Professor Andrew Pollard, the lead author of the.

All 23,745 participants were monitored for cases of severe illness and hospitalization. Twenty-one days after the first dose, all 10 patients admitted with COVID-19 were in the control group, 2 were classified as severe and 1 died.

“For the first time, we have shown that the adenovirus vector vaccine, a vaccine technology that has been in use since 2009, is effective and can contribute to disease control in the Covid-19 pandemic,” said Professor Sarah Gilbert of the University. I will. Oxford.

The authors said the first trial began in April 2020 and all disease episodes occurred within 6 months of the first dose, so the term of protection cannot yet be evaluated. Further evidence is needed to determine the term of protection and the need for additional booster vaccines, the authors said.

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The above article was published by the Wire Agency with minimal changes to the headline and text.

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