What are puberty suppressants and how do they work?

The use of adolescent inhibitors to treat adolescents with gender dysphoria or disagreement has recently been scrutinized as follows: Decision by the British High Court.. The three judges determined that children under the age of 16 were unlikely to be given informed consent to receive such treatment.

This case raises questions about the so-called impact. puberty Blockers affect the safety of drugs and their reversible effects in adolescence. The difficulty in answering these questions is the limited evidence of using these drugs in gender-incongruent adolescents, and further research is needed.

However, treating gender incongruence with puberty inhibitors is a relatively recent application, but these drugs are Children Since the 1980s to delay puberty if puberty is too early or too early.Currently, there is sufficient evidence to show that the drug is safe and well tolerated by children. Precocious puberty..

Adolescent Body glands Start producing the hormones needed to reach sexual maturity. Puberty usually occurs in girls under the age of 8 and in boys under the age of 9. However, if it happens very early or very quickly, doctors may consider using medication to delay or stop puberty.

This is done to allow the child to reach a certain percentage of the physical milestones associated with adolescence and is age-appropriate. For example, if adolescents are too early or too early, adolescents may not have enough time to grow properly.

The most common form of precocious puberty in children is the early activation of gonadotropin release. hormone (GnRH). This hormone is essential for development because the pituitary gland begins producing the hormone, and then the testes and ovaries begin producing the sex hormones testosterone and estradiol (estrogen).

However, because GnRH is spontaneously released in pulses, sustained exposure to the hormone (or its artificial version) is actually the GnRH receptor ( Pituitary gland) Effectively pauses puberty from the production of sex hormones. Receptors begin to work again and puberty resumes when exposure ceases.

The most common puberty suppressant is the GnRH analog, which is a synthetic form of the hormone. These are usually given as injections monthly or at intervals of 3 or 6 months. In general, these puberty suppressants are continued until the child is 11-12 years old. When stopped, the child resumes puberty as usual. In such cases, the girl’s menstrual period begins on average about 18 months after stopping the puberty suppressant.

In children, most evidence supporting the use of precocious puberty inhibitors to stop precocious puberty is focused on GnRH analogs.Studies show that these drugs are very effective in temporarily suspending puberty and have no effect on children. Overall height Development was once stopped.

Regarding side effects, some studies have reported weight gain from the use of puberty inhibitors, but this is Consistent discovery..Other studies have examined the effects of puberty blockers on bone health in precocious puberty children, but found nothing. Long-term problem..

Researchers have also investigated whether puberty suppressants can lead to the development of polycystic ovary in women. This condition affects the ovaries and can cause menstrual irregularities and difficulty in pregnancy.Not again Consistent findings even here.Studies showing association with secondary puberty blockers Polycystic ovary syndromeIt is unclear whether this is due to the underlying condition that caused precocious puberty or its effects. medicine itself.

Previous studies have shown no adverse effects of GnRH therapy on neurocognitive development.These medicines Generally safe and well tolerated For children with precocious puberty. When stopped, the child begins puberty and grows as expected.

Other uses

GnRH analogs are also used as fertility drugs and in the treatment of hormone-sensitive prostate and breast cancers. Gynecological condition, Endometriosis, etc.

But recently, these drugs have been used in Gender incongruence children and adolescents.. In such cases, blocking puberty allows adolescents to seek options, spend more time living in the desired gender, and avoid the development of secondary sexual characteristics such as breast and facial hair growth. I can do it.

If they and their doctor deem it appropriate, young people can start taking sex-verifying hormones, such as testosterone for transgender boys and estrogen for transgender girls. This can have irreversible effects. However, the use of GnRH analogs in these situations is temporary until a firm decision is made about the gender of the child.

However, there is still limited evidence of the effects of puberty inhibitors in these adolescents who have successfully started puberty. While puberty is blocked, it can affect growth and bone health. However, further research is needed in this area. There is also limited information on the long-term effects of adolescent depressants in gender-incongruent children and adolescents.

In general, there is clear evidence that the use of precocious puberty inhibitors in children with precocious puberty is considered safe and well tolerated, but further for long-term use of precocious puberty inhibitors in other applications. Research is needed.

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