Health
Australia’s Covid-19 vaccine trial ended after subjects returned “false positive” HIV results
The vaccination, which has not yet progressed beyond the Phase 1 trial, was co-developed by the University of Queensland and the Australian biotechnology company CSL. Australia wanted the vaccine to be available by mid-2021.
In a statement, CSL stated that no serious side effects were reported in 216 study participants, indicating that the vaccine has a “strong safety profile.” However, test data revealed that the antibodies produced by the vaccine interfered with the diagnosis of HIV and caused false positives on some HIV tests, CSL said.
If the vaccine is rolled out nationwide, the CSL said it could undermine Australia’s public health by causing a wave of false-positive HIV tests in the community.
“Follow-up tests confirmed the absence of the HIV virus, and certain HIV tests were false positives. The vaccine is unlikely to cause infection,” the statement added.
Morrison said Australia supported four promising vaccines, but “at any stage … I believed that all four vaccines were likely to go through that process.”
“That’s why we spread risk. That’s why we helped important projects. And that’s what we prepare in advance to ensure that we can deal with any issues along the way. That’s why I did it, “he said.
In addition to the University of Queensland vaccine, Australia had previously ordered a combined AstraZeneca and Novavax vaccine of 73.8 million doses.
Australia’s Health Minister Greg Hunt said after the announcement that Australia would order additional 20 million units from AstraZeneca and 11 million units from Novobax.
Vaccines must pass a three-step study before considering approval for public use. Australia has not yet approved the coronavirus vaccine candidate.
In an email statement, Adam Taylor, an early carrier research leader for the emerging virus at Griffith University’s Menzies Health Institute, said that false-positive HIV results are the result of the technology used to create the vaccine. Said.
“Molecular clamps (of vaccines) are made from HIV proteins that are harmless in their own right. Molecular clamps present the body in a way that stabilizes the coronavirus peplomer protein and promotes a good immune response. That’s the reason for the clamp. Technology is very important, “says Taylor.
He added that the clamp model vaccine showed “good safety and an immune response” against the coronavirus in early clinical trials and was considered unlikely to produce HIV-positive results.
Some Australian health professionals praise the University of Queensland researchers for completing the exam when they completed it. “It may seem counterintuitive from a research ethics perspective, but it was a success,” said Diego Silva, a health ethics expert at the University of Sydney’s School of Public Health, in an email statement. That’s it. “
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