Health
Human trials of indigenous mRNA vaccines will soon begin
India’s first indigenous people COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears According to the Ministry of Earth Sciences, mRNA vaccine candidates have been approved by the Indian drug controller General to initiate Phase I / II human clinical trials. A new mRNA vaccine candidate, HGCO19, was developed by Pune-based company Gennova and is supported by Seed Grant under the Ind-CEPI mission of the Department of Biotechnology, Ministry of Science and Technology.
Easy to develop and save
mRNA vaccines do not generate an immune response using traditional models.Instead, it carries molecular instructions for making proteins in the body through synthesis. RNA Of the virus. The host’s body uses it to produce a recognized viral protein that causes the body to initiate an immune response to the disease. According to many experts, mRNA-based vaccines are a scientifically ideal option for dealing with pandemics due to their fast development timeline. They are considered safe because they are non-infectious and are not inherently integrated. They also cannot be degraded by standard cellular mechanisms.
mRNA vaccine is cost effective
mRNA-based vaccines are expected to be very effective due to their unique ability to translate into protein structures in the cytoplasm. In addition, they are fully synthesized and do not require a host for growth such as eggs or bacteria. Therefore, it can be manufactured quickly and inexpensively under cGMP conditions, ensuring “availability” and “accessibility”. Mass vaccination On a sustainable foundation.
Animal studies show safety and efficacy
Gennova collaborated with HDT Biotech Corporation in Seattle, USA to develop this vaccine candidate, HGCO19. It has already demonstrated safety, immunogenicity and neutralizing antibody activity in animals. The neutralizing antibody response of the vaccine in mice and non-human primates was comparable to that of convalescent patients with COVID-19.
Gennova’s vaccine candidates use the most prominent variant of the spike protein (D614G) and also use a self-amplifying mRNA platform. This provides the benefits of a low-dose regimen compared to non-replicating mRNA or conventional vaccines. HGCO19 uses adsorption chemistry to attach mRNA to the surface of nanolipid carriers and enhance intracellular mRNA release kinetics compared to encapsulation chemistry.
Human experimentation to start soon
This vaccine is stable at 2-8 degrees Celsius for 2 months. Gennova has completed all preparatory work and needs to start Phase I / II humans Clinical trial Immediately after receiving approval from the DCGI office. The Biotechnology Division, in collaboration with CEPI’s Global Initiative, aims to strengthen the development of vaccines and related technologies for potentially epidemic diseases in India. Preparation: Support for vaccine development in India ”. .. DBT’s Ind-CEPI mission is implemented by its PSU, the Biotechnology Industry Research Assistance Council (BIRAC). “Establishing such a unique technology platform will not only enable India to cope with the COVID-19 pandemic, but also ensure that it is prepared for future outbreaks,” said Biotechnology Secretary and BIRAC Chair. Dr. Renuswarap said.
(With input from IANS)
Release date: December 11, 2020 22:03
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