Health
How Covid-19 takes over and damages lung cells
Boston: Scientists have deciphered the chain of molecular responses in human lung cells to a new coronavirus infection. This is an advance that may help identify clinically approved drugs that can be reused for the treatment of COVID-19.
In this study, published in the journal Molecular Cell, we evaluated manipulated cells in the air sacs of the human lung using accurate mass spectrometry techniques that can characterize the molecules present in the sample.
Based on the analysis, scientists at Boston University School of Medicine (BUSM) in the United States have identified protein and molecular pathways in lung cells whose levels change when infected with the SARS-CoV-2 virus.
Researchers believe the findings provide insight into the pathology of the disease and new therapeutic targets to block. COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears..
They found that an important type of protein modification called “phosphorylation” was abnormal in these infected lung cells.
Studies have shown that protein phosphorylation plays a major role in regulating intracellular protein function in living organisms.
It was noted that for healthy cells, both protein abundance and protein phosphorylation are usually highly regulated processes.
But scientists have discovered it SARS-CoV-2 It disrupts lung cells and causes abnormal changes in the amount of protein in these cells and the frequency of protein phosphorylation.
According to scientists, these abnormal changes help the virus multiply, eventually destroying cells and causing extensive lung damage.
Researchers said that when infected, the coronavirus began to rapidly utilize the cell’s core resources, otherwise required for normal cell growth and function.
“The virus uses these resources to multiply and avoid attacks by the body’s immune system. In this way, new viruses are formed, then exiting from exhausted and cruelly damaged lung cells and self. It will destroy it, “said Andrew Emily, co-author of the study. From BUSM.
“These new viruses infect other cells and repeat the same cycle,” Emily explained.
In this study, scientists examined alveolar cells 1 to 24 hours after infection with SARS-CoV-2, and which of these cells 1, 3, and 6 hours after infection with SARS-CoV-2. I understand how such changes will occur. -And what changes will happen later-24 hours after infection.
“Our results show that SARS-CoV-2 infected lung cells showed dramatic changes in the amount of thousands of proteins and phosphorylation events compared to normal / uninfected lung cells. “Says Darrell Kotton, co-author of the study and professor of pathology. BUSM laboratory medicine.
“In addition, our data also indicate that the SARS-CoV-2 virus induces a significant number of these changes as early as 1 hour after infection, laying the foundation for complete hijacking of host lung cells. “I showed it,” added another collaborator, Elke Muhlberger. -Research author.
Researchers have also identified at least 18 existing clinically approved drugs originally developed for other medical conditions that can be reused for COVID-19 therapy.
They believe that further research can shed light on the potential of these drugs to block the growth of new coronaviruses in human lung cells.
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