Health
How does Covid-19 hijack and damage lung cells?Scientists Decipher-World News
US scientists have reportedly deciphered the chain of molecular responses of human lung cells to coronavirus infection. This may help identify clinically approved drugs that can be reused for the treatment of Covid-19.
Conducted by scientists at Boston University School of Medicine (BUSM), the study, published in the journal Molecular Cell, uses accurate mass spectrometry techniques to identify molecules present in samples, and artificial cells in the air sack of the human lung. Was evaluated.
Based on the analysis of the study, researchers have identified pathways of proteins and molecules in lung cells whose levels change when infected with coronavirus. Scientists believe that the results of this study provide insight into disease pathology and new therapeutic targets to block Covid-19.
Researchers have found that these infected lung cells have abnormalities in an important type of protein modification called “phosphorylation.”
Studies have shown that protein phosphorylation plays a major role in regulating intracellular protein function in living organisms.
It was noted that for healthy cells, both protein abundance and protein phosphorylation are usually highly regulated processes.
However, scientists have discovered that SARS-CoV-2 disrupts lung cells and causes abnormal changes in the amount of protein in these cells and the frequency of protein phosphorylation.
According to scientists, these abnormal changes help the virus multiply, eventually destroying cells and causing extensive lung damage.
Researchers said that when infected, the coronavirus began to rapidly utilize the cell’s core resources, otherwise required for normal cell growth and function.
“The virus uses these resources to multiply while avoiding attack by the body’s immune system. In this way, a new virus is formed and then exits from exhausted and cruelly damaged lung cells. , Self-destructing, “said Andrew Emily, a research co-author of BUSM.
“These new viruses infect other cells and repeat the same cycle,” Emily explained.
In this study, scientists examined alveolar cells 1 to 24 hours after infection with SARS-CoV-2, and which of these cells 1, 3, and 6 hours after infection with SARS-CoV-2. I understand how such changes will occur. -And what changes will happen later-24 hours after infection.
“Our results show that SARS-CoV-2 infected lung cells showed dramatic changes in the amount of thousands of proteins and phosphorylation events compared to normal / uninfected lung cells. “Says Darrell Kotton, co-author of the study and professor of pathology. BUSM laboratory medicine.
“In addition, our data also show that the SARS-CoV-2 virus induces a significant number of these changes 1 hour after infection, laying the foundation for complete hijacking of host lung cells. “Another collaborator, Elke Muhlberger, added. -Research author.
Researchers have also identified at least 18 existing clinically approved drugs originally developed for other medical conditions that can be reused for Covid-19 therapy.
They believe that further research can shed light on the potential of these drugs to block the growth of new coronaviruses in human lung cells.
(With input from PTI)
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