Health
Experts identify five important genes associated with severe illness
Unpredictable nature of COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears The virus has confused and confused scientists for months, but it continues to do so. There are many ongoing studies trying to understand the complexity of this disease. The virus that causes this infection can have a more serious impact on some people than on others.From the beginning of PandemicWe have found that older people and people with underlying health are more vulnerable to the virus and are more likely to suffer from serious complications. However, over time, we have also found that COVID-19 can have similarly serious consequences for healthy young people.
According to researchers at the University of Edinburgh, potential treatments for COVID-19 have been identified after the discovery of the five genes associated with the most severe forms of the disease.According to one study, it was published in a journal Nature, Genetic evidence is second only Clinical trial As a way to know which treatments are effective for the disease. Existing drugs that target the action of genes have revealed in clinical trials which drugs should be reused to treat COVID-19, the researchers said.
Understanding at the molecular level how COVID damages the lungs
Genes involved in two molecular processes – antiviral immunity and lung inflammation – Identified. Breakthrough advances will help physicians understand how COVID-19 damages the lungs at the molecular level. The researchers made the discovery by studying the DNA of 2,700 patients in 208 intensive care units (ICUs) in the United Kingdom. A research team from the GenOMICC Consortium, a global collaborative study to study the genetics of critical diseases, has obtained genetic information from ICU COVID-19 patients from other studies such as UK Biobank, Generation Scotland, and 100,000 Genomes. Compared with samples provided by healthy volunteers. The team found significant differences in the five genes in ICU patients compared to samples provided by healthy volunteers. The genes – IFNAR2, TYK2, OAS1, DPP9, CCR2 – partially explain why some people desperately get sick with Covid-19 and others are unaffected.
Drug treatment and genetic variation
After emphasizing the genes, the team was able to predict the effect of drug treatment on the patient. This is because some genetic mutations react in the same way as certain drugs. For example, they showed that reduced activity of the TYK2 gene protects against COVID-19. A class of anti-inflammatory drugs called JAK inhibitors, including a drug called baricitinib, produces this effect. They also found that boosting the activity of the INFAR2 gene was also likely to produce protection. This is because it is likely to mimic the effects of treatment with interferon, a protein released by cells. Immune system To protect yourself from viruses.
Navigate the complexity of immune signals
However, experts warn that patients may need treatment early in the disease to be effective. In addition, clinical trials need to focus on drugs that target these specific antiviral and anti-inflammatory pathways. The genetic results of this study provide a roadmap through the complexity of immune signals and point to routes to key drug discovery targets. The results of the study immediately emphasize which drug should be at the top of the list of clinical trials.
(With input from IANS)
Published: December 12, 2020 19:17 | Updated: December 12, 2020 19:21
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
Pictures Credit
to request, modification Contact us at Here or [email protected]
 |
 |
 |
