Health
Pregnant women with COVID-19 do not pass the virus, but have less antibodies to newborns than expected
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Pregnant women may be particularly vulnerable to the development of more severe cases of COVID-19 after SARS-CoV-2 infection, but the anti-SARS-CoV-2 immune response or it in offspring Little is known about how it affects you.In a study published in JAMA network open, A group led by researchers at Massachusetts General Hospital (MGH) provides new insights that may help improve the care of these women and their newborns, and the need to consider pregnant women in their vaccine deployment plans. I emphasize it.
The study included 127 Pregnant woman Among them Third semester He was treated at three Boston hospitals between April 2nd and June 13th, 2020. Of the 64 women who were positive for SARS-CoV-2, the researchers did not detect the virus in maternal or umbilical cord blood (despite being detected in the female respiratory system). There are no signs of virus in the placenta and no evidence of viral infection in newborns. Researchers have found that not only because the mother’s blood is virus-free, but also because there are often major molecules (ACE2 receptor and TMPRSS2 enzyme) that SARS-CoV-2 uses to invade cells. We believe that the infection may be stopped. Not physically co-located on the placenta.
Most of the women who tested positive developed Antibody reaction The transfer of anti-SARS-CoV-2 antibody to the SARS-CoV-2 protein, but through the placenta, from mother to newborn was significantly lower than that of anti-influenza antibody.
“The discovery of the risk of mother-to-baby transmission of SARS-CoV-2 specific antibodies in the third trimester infection affects mothers’ vaccination. Specifically, pregnant women are involved in vaccine deployment. It emphasizes that it is an important population to consider. It raises questions about the optimal timing of vaccination to best support maternal and neonatal immunity, “said MGH maternal and fetal medicine experts. Dr. Andrea Edlow, lead author and assistant professor of obstetrics and gynecology and reproductive biology at Harvard Medical College, said.
Edrow did not expect a significant reduction in SARS-CoV-2 antibody transfer compared to antibodies to influenza, as transplacental transfer of antibodies to the fetal region is usually highest in late pregnancy. “Understanding the underlying mechanism of this inefficient transmission of SARS-CoV-2 specific antibodies after third trimester infection, vaccine-produced antibodies have the same or different properties as actual viral infections. Understanding whether or not you are is an important direction, for future research, “she says.
JAMA network open (2020). DOI: 10.1001 / jamanetworkopen.2020.30455
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Massachusetts General Hospital
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