Connect with us

Health

Pregnant women, infants at serious risk of SARS-CoV-2 infection-health

Published

on

 


In a study led by researchers at Massachusetts General Hospital (MGH), COVID-19 continue SARS-CoV-2 Infection of pregnant women and newborns.

A study published in the journal Cell reveals less than expected transmission of placenta-mediated protective SARS-CoV-2 antibodies from mothers infected in late pregnancy. The cause may be changes after the production of these antibodies. This is a process called glycosylation.

The results are based on the team’s recent findings presented at the JAMA Network Open, where pregnant women with Covid-19 do not pass the SARS-CoV-2 virus, but their antibody levels against it are also relatively low. ..

In this latest study, scientists compared maternal antibodies to influenza (influenza), whooping cough (whooping cough), and SARS-CoV-2, and how these antibodies crossed the placenta. Antibodies specific for influenza and whooping cough are relatively common methods. In contrast, not only was SARS-CoV-2 specific antibody transfer to babies significantly reduced, but the transferred antibody was less functional than the antibody against influenza. Decreased transfer was only observed with the third trimester infection.

Scientists say that changes in carbohydrate attachment to SARS-CoV-2 specific antibodies (a process called glycosylation) may be due to this reduced transfer from the mother to the foetation in late pregnancy. I found.

Carbohydrate attachment of SARS-CoV-2 specific antibodies in maternal blood was different from that seen with influenza and whooping cough specific antibodies. This carbohydrate pattern allows Covid-specific antibodies to “stack” into the maternal circulation rather than crossing the placenta through placental antibody receptors.

The increase in the total number of maternal antibodies induced by infection, and the higher placental expression of antibody receptors that attract the carbohydrate pattern of SARS-CoV-2 specific antibodies, partially overcome the problem, from mother to fetal.

Interestingly, some of the most well-transmitted antibodies were also the most functional and activating natural killer cells, which could help newborns fight the virus when exposed.

The findings influence the design of vaccines against SARS-CoV-2 for pregnant women. Vaccine regimens that can drive high levels of Covid-specific antibodies in the placenta’s preferred glycosylation pattern for selective transfer to the foetation may give better results. “Protection of newborns and babies,” said Andrea Edro, MD, a co-lead author and MGH maternal-fetal medicine expert and assistant professor of obstetrics, gynecology, and reproductive biology at Harvard Medical School.

“We are beginning to define the rules for the introduction of placental antibodies in SARS-CoV-2 for the first time, which promotes the ability to reasonably design vaccines that protect pregnant women and their newborns,” co-author. And core members Ragon Institute of MGH, MIT and Harvard, Galit Alter, PhD said.

In addition, understanding how antibody transfer is altered by trimesters may point to the most desirable window during pregnancy for vaccination to optimize protection for both mothers and infants. ..

(This story is published from the news agency feed without changing the text.)

Follow more stories above Facebook And twitter

..

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos



Pictures Credit

ExBUlletin

to request, modification Contact us at Here or [email protected]