Health
Coronavirus Pandemic: Scientists Establish Six Potential Drugs for Treatment of COVID-19
Coronavirus Pandemic: Scientists Establish Six Potential Drugs for Covid-19 Treatment
Scientists have identified six drug candidates from over 10,000 compounds to help address COVID-19. Analyzes published in the journal Nature examined the efficacy of certified drugs, medical trial candidates, and various compounds.
“There is currently no treatment option that focuses on COVID-19 or effective treatment options,” said Luke Gudat of the University of Queensland, Australia.
“In order to be able to quickly find medical lead compounds, we have launched high-throughput drug screening programs in their respective laboratories and, with the aid of the latest laptop software programs, How they bind to the virus, “said Guddat. .
The venture has focused on the primary COVID-19 viral enzyme, called the primary protease or Mpro, and plays a pivotal role in mediating viral replication, researchers said.
This makes the virus a nasty drug target, and they said that compounds that focus on it tend to be less toxic because people do not naturally have this enzyme.
“We add drugs to cell cultures that are growing enzymes and viruses, and evaluate the amount of all the compounds that the enzymes need to stop functioning or kill the virus. In some cases, there are promising compounds for additional research, “said Guddat.
After analyzing hundreds of drugs, researchers who have found six that appear to be effective in inhibiting the enzyme, one is of obvious curiosity.
“We are particularly the many leads who have taken medical tests together for the prevention and treatment of cardiovascular disease, arthritis, stroke, atherosclerosis, and a variety of issues similar to most cancers.” Guddat says:
Researchers have stated that compounds along the pipeline to drug discovery are the most popular. These are often tested at an accelerated rate as antivirals, compared to new drug leads that need to take this course from scratch.
“Our ongoing and large-scale efforts are optimistic that new candidates will be able to enter the COVID-19 drug discovery pipeline in the near future,” said Guddat.
Coronavirus Update
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