Multiple mosquito blood diets accelerate malaria transmission

Multiple blood suckings by mosquitoes reduce the incubation period of malaria parasites and increase the likelihood of malaria infection, according to a study published in the open access journal on December 31. PLOS pathogen By Lauren Childs of Virginia Tech, Flaminia Cateruccia of Harvard School of Public Health, and colleagues. Given that mosquitoes feed on blood multiple times in the natural environment, the results suggest that removal of malaria may be substantially more difficult than previously suggested in previous experiments, usually with a single blood diet. It suggests that there is sex.

Malaria remains a devastating disease for tropical and subtropical regions, accounting for an estimated 405,000 deaths and 228 million cases in 2018.In the natural environment, women Anopheles gambie Mosquitoes, the major malaria vector, eat blood many times in their lifetime. When mosquitoes are ly infected with malaria parasites, these complex behaviors are regularly overlooked, limiting their ability to accurately explain their potential impact on infection.In a new study, researchers will look at how additional blood supply affects development and potential for infection. Plasmodium falciparum Plasmodium malaria ..Gambier Hamadara Female.

“In endemic areas, we wanted to capture the fact that malaria vectors eat blood approximately every few days,” said W. Robert Shaw, the lead author of the study. “Our research shows that this natural behavior strongly promotes the potential for malaria parasite infection in previously unrecognized ways.”

The result is an additional blood supply 3 days after infection Plasmodium falciparum It accelerates the growth of malaria parasites, thereby reducing the incubation period required before infection to humans occurs. Incorporating these data into a mathematical model of sub-Saharan Africa as a whole reveals that malaria infection is more likely than previously thought and makes disease eradication more difficult. Become. In addition, reduced fertility of transgenic mosquitoes accelerates parasite growth, and control strategies using this approach aimed at controlling Anopheles mosquito populations may inadvertently promote malaria infection. Suggests that there is. Data also suggest that parasites can be transmitted by young mosquitoes that are less susceptible to pesticide killing, negatively impacting the success of pesticide-based strategies. Taken together, the results suggest that young mosquitoes and reduced fertility mosquitoes may contribute significantly to infection than previously thought.

According to the authors, the findings have important implications for an accurate understanding of the potential for malaria infection and for estimating the true impact of current and future mosquito control measures.

###

Peer review; studies; animals; cells

For coverage, use this URL to provide access to articles that are available for free at. PLOS pathogen: http: // journals.plos.org /plospathogens /article? id =10.10.1371 /journal.ppat.1009131

Quotes: Shaw WR, Holmdahl IE, Itoe MA, Werling K, Marquette M, Paton DG, etc. (2020) Multiple blood draws for mosquitoes will be shortened Plasmodium falciparum Increases the incubation period and the likelihood of malaria infection. PLoS Pathog 16 (12): e1009131. https: //Doi.org /10.10.1371 /journal.ppat.1009131

Funding: FC is funded by the Howard Hughes Medical Institute (HHMI) and the Bill & Melinda Gates Foundation (BMGF) Faculty Research Scholarship Award (Grant ID: OPP1158190, http: // www.hhmi.org), And the National Institutes of Health (NIH) (R01 AI124165, R01 AI153404, http: // www.here.government). LMC is supported by the National Science Foundation Network (NSF) (Grant ID: 1853495, http: // www.nsf.government). The findings and conclusions in this publication are those of the author and do not necessarily reflect the position or policy of HHMI, BMGF, or NIH. The funder did not play a role in research design, data collection, analysis or interpretation, publication decisions, or manuscript preparation.

Competitive Benefits: The author has declared that there are no competing interests.