Health
New drug delivery system has the potential to treat brain damage
New York:A team of researchers has created a nanoparticle platform for successful delivery of therapeutic agents to the brain. This has the potential to open up treatment possibilities for many neuropathy.
Researchers have identified biological pathways leading to neurodegenerative diseases in the last decade and have developed promising molecular agents to target them, delivering therapeutic agents across the blood-brain barrier (BBB) to the brain. It was a challenge to do.
The newly created nanoparticle platform can facilitate the therapeutically effective delivery of encapsulated drugs in mice with physically ruptured or intact blood-brain barriers, the journal Science Avances said. The published study stated.
In a mouse model of traumatic brain injury (TBI), the delivery system showed three times the accumulation in the brain of traditional delivery methods and was observed to be therapeutically effective.
Researchers believe that this study has the potential to open up treatment possibilities for many neuropathy.
Previously developed approaches for delivering therapeutics to the brain after traumatic brain injury rely on a short time frame after physical injury to the head when the blood-brain barrier is temporarily breached. ing.
However, after the blood-brain barrier has been repaired within a few weeks, doctors lack tools for effective drug delivery.
“It’s very difficult to reach both small and high molecular weight therapeutics across the BBB,” said Nitin Joshi, the corresponding author at Brigham and Women’s Hospital in the United States.
“Our solution is to encapsulate the therapeutic agent in biocompatible nanoparticles with precisely designed surface properties that allow therapeutically effective transport to the brain, regardless of BBB status. It was to do. ”
This technique allows physicians to traumatically lead to Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases that can develop months or years after the blood-brain barrier has healed. It can treat secondary injuries associated with sexual brain injury.
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