Health
The study states that COVID-19 does not expose patients with Gaucher’s disease to increased risk
Who has Gaucher’s disease If they are infected with SARS-CoV-2, the causative virus, there is no increased risk of serious illness COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears, New research shows.
The result was published in the journal Molecular genetics and metabolism, In this study “Gaucher’s disease and SARS-CoV-2 infection: experience from 181 patients in New York.. “
Gaucher’s disease is caused by a mutation in a gene GBA, Causes an abnormal accumulation of the fat molecule glucocerebroside in organs. One of the biological consequences of this abnormal accumulation is increased inflammation.
Because inflammation is also associated with SARS-CoV-2 infection, researchers hypothesize that infection in people with Gaucher’s disease may increase the risk of serious illness.
In a new study, researchers at the Lysosomal Storage Disease Program at Mount Sinai School of Medicine report findings from 181 people with Gaucher’s disease living in the metropolitan area of New York City. The survey was conducted between June and August 2020.
“As far as we know, this is the first study to systematically assess SARS-CoV-2 infection in GD. [Gaucher disease] Patients at the peak of the 2020 pandemic, “the researchers write.
Of the survey respondents, 150 were adults (mean age 50 years) and 31 were children with an average age 9 years. Type 1 left-handed, While 3 patients had Type 3 disease..The majority (85%) report Ashkenazi Jewish ancestry, and most adults (78%) processing Accompanied by enzyme replacement therapy or substrate reduction therapy for Gaucher’s disease.
In total, 25% of respondents reported experiencing at least one symptom of COVID-19, and 10% reported three or more symptoms. The most commonly reported symptoms in adults were fever, cough, and malaise. In children, the most frequent symptom was fever.
Of the adults, 45 reported exposure to COVID-19. Most of them (62%) were asymptomatic. Of the exposed adults, 33 were tested for SARS-CoV-2 infection and 10 were positive.
“One-third of adults with GD in this study reported exposure to SARS-CoV-2, but it’s encouraging that the majority of them did not report symptoms,” the researchers said. Is writing.
Of the 88 adults tested, 16 (18%) were positive for SARS-CoV-2 infection and 2 of the 6 tested children were positive. Individuals who tested positive reported significantly more symptoms on average than individuals who tested negative (4.4 vs. 0.3). Two asymptomatic patients (one adult and one child) were tested positive for antibodies to the virus. This suggests a previous infection.
According to statistical analysis, respondents who reported being very tired were significantly more likely to test positive. There was no association between gender, age, obesity index, or number of coexisting conditions and the risk of a positive test.definite GBA Mutations and Gauche-related treatments were also not associated with an increased risk of experiencing symptoms or testing positive.
No COVID-19-related deaths, hospitalizations, or visits to the emergency room have been reported. None of the survey respondents required specific treatment for COVID-19, and all were treated with over-the-counter medications at home.
“I was relieved to find that GD in a chronic metabolic inflammatory condition did not appear to be associated with a serious outcome of SARS-CoV-2 infection,” the researchers concluded.
According to the team, the limitations of this study were the fact that it was performed in a single location, that virus exposure data were self-reported by patients, and that most of the respondents were not tested for infection. included.
Marisa holds a Master’s degree in Cellular and Molecular Pathology from the University of Pittsburgh to study new genetic factors in ovarian cancer. She specializes in cancer biology, immunology, and genetics. Marisa started working at BioNews in 2018, writing about the science and health of Self Hacked and the Genetics Society of America. She also writes and composes musicals and teaches fencing clubs at the University of Pittsburgh.
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