According to a study published in the journal, an increase in circulating interleukin 6 (IL-6), an inflammatory marker in prostate cancer patients receiving androgen deprivation therapy (ADT), was associated with increased malaise. cancer..1,2
“Interleukin-6 is an pro-inflammatory cytokine that is often associated with sleep disorders and thus fatigue,” said Aasha Hoogland, lead research author and applied research scientist in the Health Outcomes and Behavior Program at the Mofit Cancer Center. The doctor said: Press release.
“Studies have shown that testosterone can suppress the effects of IL-6, but ADT limits testosterone production in the body, so elevated levels may be seen in this group of patients. “Hoogland added.
Previous studies have established an association between ADT and increased levels of fatigue, depressive symptoms, and cognitive impairment in patients. However, no studies have focused on whether ADT-induced inflammation contributes to the development of these symptoms.
“This is the first study to investigate the association between inflammation and symptoms of fatigue, depression, or cognitive impairment in prostate cancer patients undergoing ADT,” said Health Outcomes &’s corresponding author and author. Co-leader Dr. Heather Jim said. The action program at Mofit, as described in the press release.
“We believe that blockade of testosterone can increase inflammation in the body, so inflammation may also contribute to these symptoms,” Jim added.
Mofit researchers evaluated two groups of men. The first consisted of 47 patients with prostate cancer treated with ADT. Patients were evaluated at the start of ADT and 6 and 12 months after the start of treatment. The second group consisted of a cohort of 82 men with no history of cancer and age- and education-matched, evaluated at similar times.
Researchers’ strategies look at circulatory markers of inflammation in patients undergoing ADT and investigate the potential relationship between these markers and increased fatigue, depression, and cognitive impairment associated with ADT. It was that.
Circulating markers of inflammation evaluated included interleukin-1 receptor antagonist (IL-1RA), IL-6, soluble tumor necrosis factor receptor II (sTNF-RII), and C-reactive protein (CRP). It was.
Fatigue was assessed on the Fatigue Symptom Inventory, depression was assessed on the Center for Epidemiological Studies Depression Scale, and cognitive impairment was assessed using a series of neuropsychological tests.
The results showed a significant increase in fatigue, depressive symptoms, and serum IL-6 over time between patients undergoing ADT and the cancer-free group. “The rate of cognitive impairment also changed significantly between groups,” the author writes.
Over time, no significant changes were detected in IL-1RA, sTNF-RII, or CRP.
Researchers have established a link between increased IL-6 and increased malaise. However, no such relationship has been established between increased IL-6 and increased depressive symptoms or cognitive impairment.
The next step, according to Moffit researchers, is an additional study to see if certain interventions, such as exercise and anti-inflammatory treatments, can reduce fatigue and depression in prostate cancer patients undergoing ADT.
1. Inflammation caused by androgen removal therapy can cause fatigue in patients with prostate cancer. Published online on January 4, 2020. https: //bit.ly/391Yl6I. Accessed on January 4, 2020.
2. Hoogland AI, Jim HSL, Gonzalez BD, etc.Systemic inflammation and symptomatology of prostate cancer patients treated with androgen depletion therapy: preliminary findings [published online December 30, 2020].. cancer.. Doi: 10.1002 / cncr.33397
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
- Trump vows to crack down on trans people if re-elected
- What the fall of the Adani group reveals about India 1%
- Surya Paloh Stories meets President Joko Widodo for one hour 20 minutes
- Penn State Football is working towards closer college status
- Ashley Graham wears a black dress with a daring side slit
- Rare rainforests in Devon are set to be restored after a major charity donation
- Get ShakIN’ during February for Earthquake Awareness Month
- Betting on the weather is taking off
- Can the Fashion Week trash problem be solved?
- Trump news today: Trump attacks transgender rights as Nikki Haley takes on former president in 2024 race
- Consumers top Xi’s action list
- Day of chaos in UK as up to 500,000 people go on strike | protest news