Health
Pfizer / BioNTech vaccine appears to be effective against mutations in new coronavirus variants-study
New York (Reuters)-Pfizer and BioNTech’s COVID-19 vaccine is a key variant of a new highly contagious variant of the coronavirus found in the United Kingdom and South Africa, according to laboratory studies conducted by US pharmaceutical companies. Seemed to work against.
An unpeer-reviewed study by Pfizer and scientists at the University of Texas School of Medicine has shown that the vaccine is effective in neutralizing the virus with the so-called N501Y mutation in the spike protein.
Phil Dormitzer, one of Pfizer’s top virus vaccine scientists, said the mutation could be responsible for the increased infectivity and could allow the virus to evade vaccine-induced antibody neutralization. He said he was concerned.
This study was conducted on blood collected from vaccinated people. Its discovery is limited because it has not examined the complete set of mutations found in any of the new variants of the rapidly spreading virus.
Dormitzer said it was encouraging that the vaccine appeared to be effective against mutations and the other 15 mutations the company had previously tested.
“So we tested 16 different mutations, and none of them really had a significant impact. That’s good news,” he said. “That doesn’t mean 17th won’t.”
Dormitzer said he was also concerned about another mutation found in a South African variant called the E484K mutation.
Researchers plan to run a similar test to see if the vaccine is effective against other mutations found in UK and South African mutants, and within a few weeks. I hope to get a lot of data.
Scientists have expressed concern that the vaccines being deployed may not be protected from new variants, especially those emerging in South Africa.
Simon Clark, an associate professor of cell microbiology at the University of Reading, said this week that there were some new features common to both variants, but what was found in South Africa included a broader change to spikes. It has many additional mutations. “
The Pfizer / BioNTech and Moderna Inc vaccines use synthetic messenger RNA technology and can be quickly adjusted to address new mutations in the virus as needed. Scientists suggest that changes can be made in just six weeks.
Report by Michael Erman; edited by Bill Berkrot and Edwina Gibbs
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