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Update 1-COVID-19 Plasma study shows no benefit to critically ill patients

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(Add background and call for blood donation for ongoing testing)

London, January 11 (Reuters)-An international study testing convalescent plasma in the case of moderate and severe COVID-19 finds that plasma is useless and then requires intensive care in critically ill patients Has stopped registering, the test researcher said on Monday.

The REMAP-CAP study leader’s decision was the first analysis of more than 900 critical care unit participants in the intensive care unit, treated with a product that is antibody-rich plasma from people who have recovered from a pandemic disease. It was done after it was shown that it was not done. Improve the result.

“There was no evidence of harm associated with convalescent plasma administration.” (And) the study continues to recruit inpatient COVID-19 patients with moderate illness but no intensive care. The scientist leading the test said in a statement.

“It is biologically plausible that patients who do not produce antibodies at the time of convalescent plasma therapy or who have excess virus may benefit more than others. Our additional analysis will explore this, “said Manushan Kahari, a clinician and professor of critical care medicine at Guys and St. Thomas Hospitals in the United Kingdom, who co-leads the trial. It was.

He added that the initial analysis did not assess the effects of plasma on less severe inpatients. This is “still a very important issue,” he said, and will continue to be investigated in ongoing trials.

The underlying hypothesis for using convalescent plasma as a potential treatment for COVID-19 patients is that the antibodies contained in convalescent plasma neutralize the virus, block virus replication, and stop tissue damage. There is a possibility of causing it.

A small study of convalescent plasma in patients with COVID-19 in India and Argentina also showed no apparent benefit in severe or severe patients with the disease.

Analysis leading to the suspension of REMAP-CAP in critical care enrollment showed a very low probability (2.2%) of reduced mortality and reduced number of days patients need intensive care. I did.

“It is not yet known why convalescent plasma does not appear to improve outcomes in critically ill COVID-19 patients admitted to the ICU. However, it is because convalescent plasma is too advanced for lung damage. It may be because we can’t make a difference, “said Alexis Turgeon, an emergency physician and professor at Laval University in Canada, who is also working on the exam.

However, scientists and doctors called for continuing convalescent plasma testing and continuing to donate blood in the hope that recovered COVID-19 patients would help others.

“Antibodies work by stopping the virus, not by treating the symptoms,” said Gale Mifflin, a medical expert in the blood and transplant department of the United Kingdom National Health Service. “New evidence from international studies may prove that pre-intensive care use is more effective.”

REMAP-CAP is an international clinical trial investigating various potential treatments for COVID-19. We are already recruiting 4,100 COVID-19 patients for convalescent plasma trials in more than 290 clinical centers in Europe, the Americas, Asia, Africa and Australasia.

Treatment of severely ill COVID-19 patients with Roche’s Actemra or Sanofi’s Kebuzara arthritis drug significantly improves survival and the patient’s time to require intensive care, according to a study separate from REMAP-CAP It has been shortened. (Report by Kate Kelland, edited by Nick Macfie)

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