Health
Israeli researchers break through gene mutations in autism
Israeli researchers may shed new light on genetic mutations associated with autism and help scientists come up with new and more effective treatments.
Professor Sagiv Shifman of the Hebrew University found that genes associated with autism are involved in the regulation of other genes and tend to function primarily in three regions of the brain (cortex, striatum, and cerebellum). did. The cerebellum is involved not only in motor function, but also in social and cognitive functions.
Shifman collaborated with Professor Yosef Yarom, who focused on the Pogz gene, in a study published in Nature Communications. They hope that it will deepen their understanding of the relationship between the cerebellum and autism and eventually lead to new treatments.
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They studied how mutations lead to hypersocial behavior and learning disabilities in mice after they affect the proliferation of cells in the brain and inhibit the production of new neurons. This may explain why some children with mutations show heads smaller than average.
“Research using this gene, as we know it, is related to autism and has a significant impact on brain function. Great hopes of developing drugs to help children with autism. Gives us, ”says Shifman.
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