Health
Henry Ford’s study of COVID-19 hydroxychloroquine shut down quietly
A Detroit-based clinical trial, promoted in April as the first large-scale drug study on the effectiveness of hydroxychloroquine for protection from COVID-19, has quietly frozen.
Henry Ford Health System officials told Bridge, Michigan, that they couldn’t find enough participants to continue studying whether the drug could help defeat a deadly pandemic.
Hydroxychloroquine, an antimalarial drug that has also proven useful in the treatment of rheumatoid arthritis, lupus, and other inflammatory diseases, was temporarily advertised by President Trump as a potential game changer last spring. Caused excitement. However, early optimism was replaced by broader medical research, and the country’s top health agencies eventually decided that it was not effective in treating or preventing the spread of the new coronavirus.
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The Henry Ford study (WHIP COVID-19 clinical trial) found 3,000 healthcare workers, first responders, and public transport drivers to determine if hydroxychloroquine prevents COVID-19 at the forefront. Participated by hand or a family member of a healthcare professional.
Henry Ford cardiologist William W. O’Neill said in a presentation with Detroit Mayor Mike Dagan, “I know it’s very popular and I want to enroll as many people as possible. “.
Relation: FDA rejects Henry Ford’s request to use hydroxychloroquine for COVID-19
However, that optimistic view was misguided, with only 624 registered. Henry Ford quietly finished his research just before Christmas.
By then, the first US-approved vaccine by BioNTech / Pfizer has been shipped throughout Michigan using new technology designed to activate the body’s own immune system to recognize and fight the virus. Was there. The second vaccine by Moderna was approved and shipped in mid-December.
Henry Ford vaccines as “a key strategy to protect frontline workers” in ending the hydroxychloroquine study, according to an email statement to Bridge Michigan by Dr. John McKinnon, a health system infectious disease specialist. He said he was shifting his focus to and WHIPCO VID-19 co-principal investigator.
High hope fades
Detroit was desperate when the study was first published in April. Despite being only 7% of Michigan’s population, COVID deaths in the city account for almost a quarter of the state’s total population. First responders paid a particularly high price. A few days ago, Mayor Dagan revealed that nearly 500 police officers, more than 100 civilians, and more than 100 city firefighters remained in quarantine after being exposed to COVID-19. I made it.
The mayor and Henry Ford called on US Department of Health and Human Services and US Food and Drug Administration officials to expedite the trial.
“If this works, we will save the lives of the first responders in the world,” Dagan said in a statement.
Initially, antimalarial drugs seemed promising, but small studies have shown that they have some antiviral effects to treat people with COVID-19.
In July, Henry Ford researchers said they found that hydroxychloroquine, alone or in combination with the antibiotic azithromycin, improved the survival rate of 2,541 Henry Ford patients who were prematurely admitted with COVID-19. It was. President Trump tweeted approval of the study as part of his widespread push to find a solution to the deadly virus.
However, questions about the efficacy of hydroxychloroquine have already begun to become apparent among front-line clinicians, and over time by larger studies that did not show significant evidence of improvement among coronavirus patients. It was confirmed.
And Henry Ford’s work was strongly criticized by scientists and experts, including Dr. Anthony Fauci, who spoke at a parliamentary hearing., Because it has not reached the scientific rigor needed to draw such a conclusion.
In August, Henry Ford posted a letter defending the work, claiming that the study remained “promising.” Due to “the political situation that made objective discussions about this drug impossible,” the letter said Henry Ford would no longer comment on hydroxychloroquine “outside the medical community.”
More news arrived in the fall. In October, the World Health Organization released findings showing that the drug “had little or no effect” on the mortality rate of hospitalized COVID patients.
According to a peer-reviewed Journal of the American Medical Association’s November editorial, Trump’s remarks on the drug contributed to “misuse of hydroxychloroquine” in cases of coronavirus.
That same month, a peer-reviewed Lancet Medical Journal study noted that there was no significant difference in COVID rates among people who were taking hydroxychloroquine for other reasons, such as lupus.
On December 21, Henry Ford warned the federal database of clinical trials that the trial would be terminated. Henry Ford officials who refused the interview despite repeated requests are now informing trial participants, according to a statement to Bridge.
In addition to the low participation rate, Henry Ford researchers say that “the infection rate is very low” among the participants in the study and “very likely” to identify whether the drug is effective. That’s not true, “he said.
Hospital officials said they were analyzing the data they collected and would submit it to the US Food and Drug Administration when completed.
Detroit Free Press, Bridge Michigan, and Michigan Radio have collaborated to report on a hospital in Michigan during a coronavirus pandemic. If you work in a hospital in Michigan, please contact us. You can contact Kristen Jordan Shamus ([email protected]), Robin Erb ([email protected]), or Kate Wells ([email protected]).
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