Health
Gut flora and severity of COVID-19: new evidence of link
Laboratory studies suggest that the gut flora can affect the severity of COVID-19.
Patients with reduced levels of certain types of bacteria were associated with increased levels of inflammatory cytokines and blood markers such as C-reactive protein, lactate dehydrogenase, and aspartate aminotransferase, said Dr. Siew Ng of the Chinese University of Hong Kong. Reported a colleague., To Intestines..
Researchers have found that patients with severe disease show high plasma levels of inflammatory cytokines and inflammatory markers, and given the altered intestinal microflora composition of SARS-CoV, the gastrointestinal tract in SARS-CoV-2 infection. Noted that there is “substantial involvement” in. -Two infected people. They hypothesized that the gut flora was associated with the inflammatory immune response of the COVID-19 host.
The authors examined blood and stool samples from 100 positive COVID-19 patients identified at two hospitals in Hong Kong from February to March 2020. This includes 27 consecutive stool samples out of 100 patients up to 30 days after SARS-CoV-2 clearance. Eleven patients had hypertension, but less than five had other comorbidities. A total of 41 patients provided multiple stool samples during hospitalization and / or post-discharge follow-up.
The average age of the patients was about 36 years and 53 were male. Almost all patients had mild or moderate illness, with only 5% having severe illness and 3% having severe illness.
These patients had more compared to the adult control group without COVID-19 Ruminococcus gnavus, Ruminococcus Torque, And Bacteroides dray Species regardless of whether the patient received medication.
Examining a sample of 87 patients with COVID-19 in the hospital, researchers found that among mild, moderate, severe, and severe patients, “stratification of gut flora composition associated with disease severity”. I found “a continuum” that shows the transformation. Measurements of cytokines and certain enzymes from plasma were “significantly associated with microbiota composition” and, in fact, “increased with microbiota composition representing more serious medical conditions”.
“These results suggest that the composition of the gut flora is associated with the magnitude of the immune response to COVID-19 and subsequent tissue damage and therefore may play a role in regulating the severity of the disease. I’m doing it, “they wrote.
They found that this role of gut flora contributed to a “microbiome-based risk profile” to identify people at risk for inflammatory symptoms such as pediatric multisystem inflammatory syndrome (MIS-C) and severe illness. Suggested that there is a possibility.
In addition, this is a potential reason for COVID-19 symptoms such as fatigue, dyspnea, and arthralgia, as a small number of patients showed dysbiosis of the intestinal flora even 30 days after SARS-CoV-2 clearance. I found that it could be a symptom. It tends to persist after recovery.
Data limitations include heterogeneous patient management that may have affected microbial characteristics. The authors noted that more controlled studies are needed to confirm these findings, as it is unclear how much of the gut flora is affected by patient management.
“The observed composition of the gut flora may not be directly related to the severity of the disease, but may simply be a response to the patient’s health and immune status. Therefore, subjects other than COVID-19 It may not be directly applicable to predicting disease susceptibility, “they write. ..
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Disclosure
This study was supported by the Health Research Fund, Food and Health Administration, Hong Kong SAR Government, Hoi Hoi & Cho Shin Lan Charity Fund, Matsu and Crane, Hoi Min, DH Chen. Foundation.
The authors do not disclose their relationship with the industry.
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