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Sleep disorders and muscle weakness persist for 6 months after COVID-19

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Among patients hospitalized for 2019 coronavirus disease (COVID-19) in Wuhan, China, symptoms of fatigue and weakness, and sleep Difficulties have been shown to persist in more than 1 in 4 patients after 6 months. In addition, over 75% of patients reported at least one persistent symptom. Survey results Published last week Lancet..

As the number of cases of COVID-19 continues to grow exponentially around the world, researchers emphasize that the long-term health effects remain largely unknown.

Dr. Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases and a top US infectious disease expert Keynote speech so American Heart Association Science Session 2020 For weeks and months after being infected with COVID-19, up to one-third of people live with symptoms such as severe fatigue and shortness of breath. However, he said long-term follow-up is still needed to understand the effects of prolonged illness.

In a current bidirectional cohort study, researchers explain the long-term health effects of Wuhan’s COVID-19 patients discharged from Kingintan Hospital between January 7, 2020 and May 29, 2020. Attempted (n = 1733; median age, 57 years; 52% male). They also investigated related risk factors, especially the severity of the disease.

Participants were interviewed via a questionnaire assessing their symptoms and health-related quality of life, had a physical examination, a 6-minute walk test, and had a blood test. The severity of the illness was characterized by the highest seven category scales during hospitalization:

  • 1 – Resume normal activity and not be hospitalized
  • 2 – Not hospitalized but unable to resume normal activity
  • 3 – Admitted to the hospital but does not require oxygen supplementation
  • 4 – Hospitalized but needs oxygen supplementation
  • 5 – Admitted to a hospital that requires high flow nasal cannula, non-invasive ventilation, or both
  • 6 – Admitted to a hospital that requires extracorporeal membrane oxygenation, invasive ventilation, or both
  • 7 – Death.

“Registered patients who participated in Lopinavir exam I underwent a severe acute respiratory syndrome coronavirus 2 antibody test for SARS-CoV-2 suppression in China, “the researchers added. “We used a multivariable-adjusted linear or logistic regression model to assess the association between disease severity and long-term health effects.”

Fatigue and weakness (63%) and sleep disorders (26%) are the most common symptoms, based on findings from a follow-up study conducted from June 16th to September 3rd, 2020. did. Additional symptoms reported included anxiety and depression, which were found in 23% of patients.

In particular, patients with more serious illness during hospitalization showed more severe pulmonary diffuse disability and abnormal chest imaging symptoms on scales 5-6. These patients also had poor performance on the 6-minute gait test, with 29% failing to reach the lower limit of the normal range.

The study also addressed significant concerns among people already infected with COVID-19. Within a group of 94 patients, neutralizing antibody levels dropped by an average of 53% during the 6-month study period after their illness peaked.

“These results confirm that people with severe illness need post-discharge care,” the study authors conclude. “Understanding the full range of health effects of COVID-19 requires longer follow-up studies in larger populations.”

reference

6-month results of COVID-19 in Huang C, Huang L, Wang Y, and other discharged patients: Cohort study. Lancet.. Published online on January 8, 2021. doi: 10.1016 / S0140-6736 (20) 32656-8

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