Wednesday, January 13, 2021 (HealthDay News)-New studies suggest that bacteria in the gut may affect the severity of COVID-19 infection and the strength of the immune system response.
Not only that, microbiome imbalances can cause persistent inflammatory symptoms, often referred to as “long-distance” COVID, the researchers added.
“Microbiome imbalances contribute to the severity of COVID-19 and, if persisted after viral clearance, can contribute to persistent symptoms and multisystem inflammatory syndromes such as long-term COVID syndrome,” said Senior Researcher. Dr. Siew Ng Institute for Gastroenterology, Hong Kong Chinese University.
“Recovery of lost beneficial bacteria may boost immunity to the SARS-CoV2 virus and speed recovery from the disease,” she said. “Management of COVID-19 should be aimed not only at removing the virus, but also at restoring the intestinal flora.”
However, the study cannot prove that microbiome imbalances cause aggravation of COVID-19, only appearing to be a link between the virus and the bacteria in the gut, Ng said. Said.
However, she said there is increasing evidence that gut bacteria are associated with inflammatory diseases.
In this study, researchers studied blood and stool samples from 100 COVID-19 patients and 78 uninfected stool samples that were part of a microbiota study before the pandemic began.
They found that in 274 stool samples, the gut flora was significantly different between patients with and without COVID-19, regardless of whether they were given drugs containing antibiotics.
For example, people with COVID-19 had fewer types of bacteria that could affect the response of the immune system than people who were not infected. The decrease in the number of these bacteria was associated with the severity of the infection.
In addition, researchers found that the numbers of these bacteria remained low until 30 days after the infected patient cleared the virus.
COVID-19 induces the immune system to make inflammatory cytokines, which in some cases can lead to excessive tissue damage, septic shock, and organ failure.
Analysis of blood samples revealed that microbial imbalances in COVID-19 patients were associated with blood markers of tissue damage such as high levels of inflammatory cytokines and C-reactive proteins.
One US expert who did not participate in the study pointed out that his microbiota responds to all kinds of conditions that may or may not be associated with COVID-19.
Dr. Arun Swaminas, director of gastroenterology at Lenox Hill Hospital in New York City, said: “It is clear that stool biodiversity changes depending on many factors, including age, diet, underlying autoimmune disease, and exposure to antibiotics.
The key question is whether these changes are specific to COVID-19 or are common in patients with illnesses who may have been hospitalized for non-COVID-related illnesses.
“Some of the data initially published in populations with altered gut flora, such as patients with COVID-19-infected inflammatory bowel disease, did not experience adverse results compared to the general population, so The idea of altering the gut flora at baseline does not seem to mean exacerbation of inflammation with COVID-19, “Swaminus said.
“But Ng’s studies may help identify people who haven’t recovered from COVID-19 infection using stool biodiversity tests,” he added.
The report was published online in the journal on January 11th. Intestines.
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Harvard University There are more information about Microbiome.
Source: Siew Ng, MD, PhD, Professor, Institute of Gastroenterology, Chinese University of Hong Kong; Ph.D. in Gastroenterology, Lenox Hill Hospital, New York City. Intestines,January. November 2021, online
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