Connect with us


Researchers may destroy molecules that cause excess mucus in the lungs, driving new treatments for lung disease-ScienceDaily




Lung mucus can be fatal to asthmatics, but scientists at the University of Colorado Anschutz Medical Campus have broken down these secretions at the molecular level, often reversing the fatal effects.

In a study published in the journal on Monday Nature CommunicationsResearchers have described how they created an inhalation therapy that interferes with the production of excess mucus by reducing disulfide bonds and opening the airways in mice. The same treatment had a similar effect on human mucus samples.

“Currently, about 10% of the population suffers from asthma,” said Dr. Christopher Evans, a professor of lung science and critical care at CU School of Medicine, the lead author of the study. “Excessive mucus blocks airflow, causes wheezing, and exacerbates the effects of inflammation and contraction of the muscles that line the airways.”

However, treatments for asthma, such as bronchodilators and steroids, are rarely effective against mucus. Evans said the mucus is hydrated to make it easier to cough, but the problem cannot be treated at the molecular level.

He and his team targeted macromolecules in mucus called macromolecular mucin glycoproteins. They help protect the lungs and respiratory tract from infection in healthy people. However, overproduction can create gelatinous plugs that block the airways, as seen in asthma and other lung conditions.

Researchers sought to stop this process by breaking mucin disulfide bonds, which contribute to mucus overproduction. They treated asthmatic mice with a chemical known as TCEP (Tris (2-carboxyethyl) phosphine). It also acted on human mucus sampled from asthma patients.

“We have shown that disruption of mucin disulfide bonds loosens mucus and reverses the pathological effects of mucus hypersecretion in a mouse allergic asthma model,” said a postdoctoral fellow at CU Anschutz, co-author of the study. Dr. AnaMaria Jaramillo said. “Loosening mucus reduces airway inflammation, enhances mucus fimbria clearance, and eliminates airway hyperactivity.”

Researchers say TCEP is likely to irritate the human lungs, but adds something similar to drugs that treat asthma, COPD, cystic fibrosis, and other lung diseases to reduce mucus. Said that it was much more effective.

“This kind of strategy can be used to develop safer mucolytic compounds,” says Evans. “They were able to help steroids and albuterol penetrate deep into the lungs and airways. They could be used as adjuvant therapy.”

These new compounds may also be used to treat COPD, pulmonary fibrosis, and infections such as pneumonia and Covid-19 that attack the lungs and airways.

“These findings establish a basis for developing treatments that reduce the effects of hypersecretion of mucus in asthma,” Evans said. “I believe they have the potential to save lives.”

Story source:

material Provided by University of Colorado Anschutz Medical Campus.. Original written by David Kelley. Note: The content can be edited in style and length.


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]