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“Microbiota” can affect the severity of COVID-19

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Wednesday, January 13, 2021 (HealthDay News)-Bacteria in the intestine can affect the severity and fitness of COVID-19 infection Immune system Response, new research suggests.

Not only that, microbiome imbalances can cause persistent inflammatory symptoms, often referred to as “long-distance” COVID, the researchers added.

“Microbiome imbalance contributes to the severity of COVID-19 and may contribute to persistence if it persists after viral clearance. Symptoms And multi-system inflammation A syndrome like the long COVID syndrome. ” Dr. Siew Ng, a senior researcher who is a professor at the Institute of Gastroenterology, Chinese University of Hong Kong, said.

“Recovery of lost beneficial bacteria may boost us Immunity It fights the SARS-CoV2 virus and speeds recovery from the disease, “she said.

However, the study cannot prove that microbiome imbalances cause aggravation of COVID-19, only appearing to be a link between the virus and the bacteria in the gut, Ng said. Said.

But the evidence continues to grow Gut flora She said it was associated with inflammatory disease.

In this study, researchers studied blood and stool samples from 100 patients with COVID-19 and 78 uninfected patients. Pandemic I started.

They found that in 274 stool samples, the gut flora was significantly different between patients with and without COVID-19, regardless of whether they were given drugs containing antibiotics.

For example, people with COVID-19 had fewer types of bacteria that could affect the response of the immune system than people who were not infected. The decrease in the number of these bacteria was associated with the severity of the infection.

In addition, researchers found that the numbers of these bacteria remained low until 30 days after the infected patient cleared the virus.

COVID-19 induces the immune system to make inflammatory cytokines, which in some cases can overwhelm this reaction and cause widespread tissue damage. Septic shock And organ failure.

Analysis of blood samples revealed that microbial imbalances in COVID-19 patients were associated with blood markers of tissue damage such as high levels of inflammatory cytokines and C-reactive proteins.

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