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Blood sample analysis showed significant differences in several groups of metabolites-ScienceDaily




Blood sample analysis shows that at 2-5 years after delivery, mothers of children with autism spectrum disorders (ASD) have some significantly different biotransformation levels compared to mothers of normally developing children. Shown.It’s according to a new study published recently BMC Pediatrics By an interdisciplinary team from Rensselaer Polytechnic Institute, Arizona State University, and Mayo Clinic.

The researchers analyzed blood samples from 30 mothers whose young children were diagnosed with ASD and 29 mothers of typically developing children. At the time the sample was taken, the female child was 2 to 5 years old. The team found some differences in biotransformation levels between the two groups of mothers. Upon further investigation, researchers were able to group these differences into five subgroups of correlated metabolites. The samples analyzed were taken years after pregnancy, but the results of these studies raise the question of whether biotransformer differences may also be present during pregnancy, and further research in this area Suggests that is needed.

Many of the differences are associated with low levels of folic acid, B12 vitamins, and carnitine-binding molecules, according to researchers. Carnitine is produced by the body and is obtained from meat sources such as pork and beef, but there was no correlation between mothers who ate more meat and mothers who had higher levels of carnitine.

According to Jürgen Hahn, head of biomedical engineering at Lenselia and co-author of the treatise, the findings relate to how carnitine is metabolized in some mothers’ bodies. It suggests that you may be doing it.

“There were multiple metabolites associated with carnitine metabolism,” said Hahn, who is also a member of Renseria’s Center for Biotechnology and Interdisciplinary Research. “This suggests that carnitine and mothers should be noted.”

The team’s big data approach has proven to be very accurate in predicting which group a mother belongs to using blood sample analysis. This suggests the development of blood tests to screen mothers at high risk of having children with ASD. It may be possible.

“A blood test doesn’t tell if a child has autism, but it does tell if he’s at high risk,” Hahn said. “And in this case, the higher risk classification can actually be important.”

“Based on these results, we are conducting a new study of stored blood samples collected during pregnancy to determine if these metabolites are also different during pregnancy,” said James, Department of Material Transport Engineering.・ Professor Adams said. Director of Energy, and Arizona State University’s Autism / Asperger Research Program. Adams co-authored this treatise with Hahn.

This study is based on Hahn’s other studies. He previously discovered a pattern of specific metabolites in the blood of children with autism that could be used to better predict the diagnosis. He used this same method to investigate the risk of mothers with children with ASD. He and Adams also did a similar job studying autistic children with chronic gastrointestinal problems.

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material Provided by Rensselaer Polytechnic University.. Note: The content can be edited in style and length.


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