Scientists are developing DNA tests to identify pneumonia in patients with severe COVID-19 | Weather Channel-Weather Channel Articles

Researchers have developed a DNA test to quickly identify secondary infections in COVID-19 patients who are at twice the risk of developing pneumonia during ventilation.

For patients with the most severe forms of COVID-19, mechanical artificial respiration is often the only way to keep the patient alive, as doctors use anti-inflammatory therapy to treat inflamed lungs. .. However, these patients are vulnerable to additional bacterial and fungal infections that may be acquired during hospitalization, the so-called “ventilator-related pneumonia”.

“Early in the pandemic, we realized that patients with COVID-19 were at particular risk of developing secondary pneumonia and began using the rapid diagnostic tests we developed for that very situation,” co-author Andrew. Conway Morris said. From Cambridge University.

“Using this test, we found that patients with COVID-19 were twice as likely to develop secondary pneumonia as other patients in the same intensive care unit,” Conway added. ..

Bacterial samples from patients usually need to be cultivated and propagated in the laboratory, which is time consuming and difficult to confirm the diagnosis of pneumonia. According to a paper published in the journal, this test takes a different approach by detecting the DNA of various pathogens. Critical care..

This test uses multiple polymerase chain reactions (PCRs) that detect bacterial DNA and can be done in about 4 hours. That is, you don’t have to wait for the bacteria to grow. IT can run multiple PCR reactions in parallel to simultaneously detect 52 different pathogens that often infect the lungs of patients in the intensive care unit. At the same time, antibiotic resistance can be tested.

“Patients with COVID-19 are more likely to develop secondary pneumonia, but the bacteria that caused these infections were found to be similar to those in ICU patients without COVID-19,” said Varsity. Lead author Mailis Maes said.

“This means that standard antibiotic protocols can be applied to COVID-19 patients,” Maes added.

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