Scientists have designed vaccine candidates that induce protection in mice against the “widespread associated coronavirus.” This is an innovation that may help protect against potentially pandemic viruses that will jump from animals to humans.
The new “mosaic nanoparticles” vaccine described in the scientific journal is shaped like a cage made up of 60 identical proteins, each with a small protein tag that acts like a velcro. I will.
In this study, scientists, including Alex Cohen of the California Institute of Technology (Caltech) in the United States, evaluated various coronavirus spike protein fragments and each had a protein tag that binds to a protein tag on the cage. Designed-Located on the other side of the “Velcro”.
When these pieces of virus tag the cage, the nanoparticles present spikes on its surface that represent various coronavirus strains.
Scientists have stated that the vaccine platform can generate a variety of antibody responses using eight different coronavirus spike fragments. This is superior to traditional vaccine methods that present fragments from only a single type of virus.
Studies have shown that antibodies subsequently produced by mice vaccinated with vaccine candidates were able to react with many different strains of coronavirus.
Scientists said some of the mouse antibodies were surprisingly responsive to coronavirus-related strains in which the peaplomer was not present on the nanoparticles.
“If we can show that the immune response elicited by our nanoparticle technology actually protects against infection-induced diseases, we hope that this technology can be advanced into human clinical trials. But there are many steps that need to take place in the meantime, “cohen said.
“I don’t think this methodology will replace existing vaccines, but it’s good to have many tools at hand when faced with the threat of new viruses in the future,” he adds. I did.
Scientists believe that the SARS-CoV-2 virus that causes COVID-19 is unlikely to be the last coronavirus that causes a pandemic.
“Alex’s results show that it is possible to trigger a variety of neutralizing antibody reactions, even against coronavirus strains that are not represented in the injected nanoparticles,” the study co-authors said. Pamela Björkman of the California Institute of Technology said.
“In addition, nanoparticles induce a neutralization reaction to SARS-CoV-2, which could allow them to be used to protect against COVID-19 and other potentially pandemic coronaviruses.” Bjorkman added.
This story was published from the Wire Agency Feed without changing the text. Only the heading has changed.
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