Health
What does a coronavirus mutation mean?
Read: Coronavirus is evolving in front of you
The role of the individual mutations is still unknown, but it is worth noting that the specific mutation in the peplomer protein called N501Y is found in all three variants. Peplomers are the way coronavirus invades cells, and N501Y is located in a particularly important region called the receptor binding domain, which latches into cells. The N501Y mutation may make the peaplomer more sticky, making it easier to bind and invade cells. Such viruses can be more susceptible to infection.On the plus side, however, mutations do not seem to have any effect. Immunity from vaccine..
By the way, how to read the name of the mutation is as follows. Proteins are made up of components called amino acids. N501Y means that the 501st amino acid was originally N and represents the amino acid asparagine, but Y has been modified to represent tyrosine.
However, the N501Y is not unique to these three variants.It was found in many sequences In the world.. What is unusual for these three variants is that there are also additional constellations of other mutations in other parts of the virus. Changes in mutant behavior, such as increased transmission, are probably “due to multiple mutations, not just one,” said Emma Hodcroft, a molecular epidemiologist at the University of Bern. The British variant has more than 12 other mutations that have not been as scrutinized as the N501Y. However, the improvement in variant transmission is more certain. It is becoming more widespread not only in the UK but also in the UK. Ireland And Denmark, Two other countries that regularly sequence a large number of samples. CDC recently Predominant variants in the United States by March..
(Scientists have given all three variants more specific names, Unfortunately, they haven’t standardized them yet. The UK variant is also known as B.1.1.7, 20I / 501Y.V1, and VOC202012 / 01. The South African variant is sometimes referred to as B.1.351 or 20C / 501Y.V2. Brazilian variants are known as P.1 and 20J / 501Y.V3. )
South African and Brazilian variants also have a common second and third mutation. Spike receptor binding domain: E484K and K417. Scientists know a little more about the E484K mutation. Switch negatively charged amino acids to positively charged amino acids. It’s like flipping a magnet over. This can change the shape of the peplomer as it binds to the cell, which seems to act synergistically with the N501Y mutation. These mutations, along with other mutations, may improve the binding of the virus to cells.
Read: Why don’t we wear better masks?
However, South African and Brazilian variants may have additional benefits.Recent studies have shown that viruses with the E484K mutation Excellent in avoiding antibodies From the recovered plasma of COVID-19 patients. Some viruses with this mutation can be a little better at re-infecting people and infecting vaccinated people.
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