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A plant-based Mediterranean diet cuts NAFLD in half

 


January 19, 2021

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Disclosure: Meir has not reported disclosure of relevant financial information. See the survey for a list of relevant financial disclosures for all other authors.

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Studies show that a Mediterranean diet restricted to red / processed meat in combination with green plant-based proteins / polyphenols can double the loss of intrahepatic fat and cut non-alcoholic fatty liver disease in half. There is sex.

“This trial introduces a new concept. Green mediterranean dietCertain green polyphenols, such as mankai, green tea, and walnuts, are further fortified and processed with red meat, which can significantly double the reduction in intrahepatic fat compared to other healthy nutritional strategies. Limited to meat. Anat Yaskolka Meir, MPH, RD, Written by Harvard TH Chan School of Public Health and colleagues from the Department of Epidemiology, Boston.

Patients in the MED and Green MED groups consumed 28 g of walnuts per day.

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In an 18-month study of DIRECT-PLUS, Meir et al. Randomly assigned 294 patients with abdominal obesity / dyslipidemia to one of three weight loss groups (healthy eating guidelines, Mediterranean or Green MED). I did. Physical activity was also included in all groups. Patients in the equical MED group consumed 38 g of walnuts per day. In addition, the Green MED Group consumed 3-4 cups of green tea and Mankai Green Shake per day. Researchers used proton magnetic resonance spectroscopy to quantify the rate of change. Liver fat (IHF) 18 months under study.

Patient retention was 89.8% and 78% were eligible follow-up MR spectroscopy. Researchers reported that the prevalence of NAFLD was reduced to 54.8% in the healthy diet guidelines group, 47.9% in the MED diet group, and 31.5% in the green MED diet (31.5%).P = .012).

“Despite similar moderate weight loss in both MED groups, the Green MED group suffered almost twice the IHF% loss (proportional –38.9%) compared to MED (proportional –19.6%). Achieved. P = .035 Weight Loss Adjusted) and [healthy dietary guidelines] (Proportionately – 12.2%; P <.001) ", the investigator wrote.

Both MED diet groups had significantly higher total plasma polyphenol levels than the healthy diet guideline group.In addition, researchers have observed more quantities Naringenin 2-5-Dihydroxybenzoic acid from the Green MED Diet Group.

“Increased IHF% loss includes increased mankai and walnut intake, reduced lean / processed meat consumption, improved biomarkers of serum folic acid and adipocaine / lipids, microbiome composition (beta diversity) and identification. Was independently associated with changes in bacteria (beta diversity)P <.05 all) ", writes Meir and colleagues.

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