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Researchers Discover Potential New Treatments for Chemotherapy-Resistant Breast Cancer



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Scientists have discovered a molecule that can selectively kill cells in subtypes of breast cancer that are difficult to treat. This can lead to new treatments.

The study, led by researchers at the RCSI University of Medical and Health Sciences, is published in its current edition. Science Advances..

Triple-negative breast cancer is a subtype of breast cancer that is primarily treated with chemotherapy. Unfortunately, up to 70% of patients with this form of breast cancer are resistant to treatment.

Researchers have tested various molecules to see if they can selectively kill cells in this type of breast cancer while saving them. .. They found that a specific molecule, BAS-2, could do this.

“Our current goal is to evaluate the availability of new functions that may improve the treatment of patients by developing small molecules into more drug-like compounds,” the study responded. Dr. Tríona Ní Chonghaile, author and RCSI instructor, said. Physiology and medical physics.

To better understand how the molecule killed cells, researchers confirmed that it inhibits an enzyme called HDAC6.State-of-the-art use For the first time, researchers have identified that HDAC6 plays an important role in altering the energy of these cancer cells.

HDAC6 can control tumor growth and stop metastasis of triple-negative breast cancer

For more information:
Catríona M. Dowlingetal, a multiple screening approach, revealed that HDAC6 is a novel regulator of glycolytic metabolism in triple-negative breast cancer. Science Advances (2021). DOI: 10.1126 / sciadv.abc4897

Provided by RCSI

Quote: Researchers have obtained chemotherapy-resistant breast cancer (2021) from on January 19, 2021. Discovered a potential new treatment (January 19, 2014)

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