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California Coronavirus Variant – NBC7 San Diego

 


A new strain of coronavirus, CAL.20C, may have helped accelerate the recent surge in cases across Southern California, according to a study published this week.

This strain, designated by researchers as CAL.20C, is believed to be part of the cause of the dramatic increase in cases over the last two months. Findings from Cedars-Sinai researchers did not indicate whether this strain was more lethal than other current forms of coronavirus.

NBC 7’s Dave Summers talked to a local doctor about it all tonight.

“Notably, it’s more contagious, or it’s becoming more frequent because of founder effects and biases,” said Christian Andersen, a professor of immunology and microbiology at the Scripps Research Institute in San Diego. It’s very unclear if this is the case. ” In a statement released Wednesday, Diego said, “The virus is constantly mutating, and some variants are more frequent due to sequence bias, sampling bias, nearby super-spreading events, and founder effects. It will increase (sometimes rapidly). It is unclear where in the big picture this particular variant falls. ”

Andersen, who led the Scripps Research team, detected one of the first cases of B.1.1.7 in the United States (also known as a British variant) in San Diego.he Told the New York Times It is not yet known if the variants found in California have any biological advantage, or if some statistical anomalies are simply becoming more common.

Anderson also said that if social distance, large-scale testing and screening, avoidance of meeting settings, etc. could actually prevent most of the spread, researchers would say “functional variants.” He said the surge in “change” should not necessarily be blamed. Of course, wear a mask.

CAL.20C is considered to be highly infectious, unlike the B.1.1.7 version, which is also popular in the United States.

In Southern California, B.1.1.7 has been found in cases of coronavirus scattered throughout the counties of Los Angeles, San Diego, and San Bernardino. In contrast, the CAL.20C strain was identified in 36.4% of the cases in the Cedars-Sinai study.

CAL.20C contains variants of the virus reported by the California Public Health Service on Sunday, based on data submitted by Cedars-Sinai and other investigators.

Three COVID-19UK variants have been reported in San Diego County, and health leaders are hoping for more, reports Melissa Adan of NBC7.

This mutant, called L452R, is one of the five repetitive mutations that make up the CAL.20C strain that has spread nationwide starting in Los Angeles County.

“The recent surge in COVID-19-positive cases in Southern California is consistent with the emergence of CAL.20C,” said Eric Vail, Assistant Professor of Pathology and Dean of Molecular Pathology at Cedars-Sinai’s School of Pathology and Laboratory Medicine. The doctor says. ..

Vail was submitted to MedRxiv.org, an online archive of unrefereed health science manuscripts, co-author of this study, and was submitted for peer review on Thursday at the same time.

“We are still learning a lot about what [L452R variant] That is, working hard with tremendous genomic sequencers in state institutions such as UCSF and Scripps, and working with the CDC and local public health partners, what role this variant plays in our transmission rates. Continue to determine if you are playing a role. Dr. Mark Garry, Secretary-General of the University of California, Health and Welfare, said Tuesday in a weekly update on the coronavirus.

According to Garry, the variant was first identified last year in several other countries and states, including California.

“We know that we have recently been identified in some large outbreaks in Santa Clara County-some of those outbreaks in the congregation care facilities we know are extensive and large. It’s easy to get out of control, “Ghaly said. Determine if it is actually more infectious and how it can affect vaccination.

Garry emphasized concerns about the emergence of new variants.

“The concern about all kinds of variants is that it changes the behavior of the virus,” Ghaly said on Tuesday. “Viruses are always mutated. RNA viruses are notorious and are known to have more mutations than other viruses. So are they important variants? Affecting levels of infectivity? Affect? ​​Affect? ​​Viral, level, severity of illness? We continue to learn as much as possible as soon as possible … so far … additions about mutations that were here in California There is no news. “

Researchers using publicly available databases have also detected CAL.20C strains in several recent patient samples in Northern California, New York, Washington, DC, and Oceania.

To identify the CAL.20C strain, Cedars-Sinai researchers conducted SARS from 192 patients with Cedars-Sinai who were coronavirus-positive between 22 November and 28 December 2020. -I examined the CoV-2 virus sample.

They used advanced technology known as next-generation sequencing to analyze the genes of the virus. They combined this data with 4,337 gene profiles of the SARS-CoV-2 virus from patients throughout Southern California, using a database also publicly available.

The CAL.20C strain was almost non-existent in October, but by December, 36.4% of virus samples from Cedars-Sinai patients were determined to be strains, and 24% of all Southern California samples were. , Imperial, Kern, Loss. The counties of Los Angeles, Orange, Riverside, San Bernardino, San Diego, San Luis Obispo, Santa Barbara, and Ventura.

“The double-digit epidemic of the CAL.20C strain in November and December was first observed in July 2020 in one of 1,230 virus samples in Los Angeles County and was detected again in Southern California until October. It was impressive considering that it wasn’t there, “said a research scientist at the Cedars-Sinai Center for Bioinformatics and Functional Genomics, a deputy director of the Applied Genomics, Computational and Translation Core at Cedars-Sinai, and other co-directors. The author, Jasmine Plummer, said.

Wenjuan Zhang, an assistant professor of pathology and laboratory medicine at Cedars-Sinai and the first author of the study, said the research team “doesn’t know what new discoveries about CAL.20C infectivity and antibody resistance mean.” Said. Strain. This is important for follow-up surveys that need to be completed. “

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