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Researchers Discover Powerful Protein Doubles Running Capacity and Improves Physical Performance – NBC Los Angeles

 


Humans express powerful hormones during exercise, and treating mice with hormones improves their physical fitness, ability, and fitness, according to a new USC study released Wednesday.

Researchers say the findings offer new possibilities for coping with age-related physical decline.

Published in the scientific journal Nature Communications, this study details how the mitochondrial genome can encode instructions for regulating physical performance, performance, and metabolism during aging and prolong healthy lifespan. Clarify the consideration.

“Mitochondria are known as a source of energy for cells, but they are also hubs that regulate and fine-tune metabolism by actively communicating with other parts of the body,” said Changhan David Lee, an assistant professor at the USC Leonard Davis School of Gerontology. Mr. says. Corresponding author of the study.

“As we get older, the communication network seems to be broken, but our research is to restore the network or rejuvenate old mice to fit as much as young mice. It suggests that you can do it, “Lee said.

This study investigated the role of MOTS-c, one of several recently identified hormones known to mimic the effects of exercise. However, MOTS-c is unique because it is encoded in a small mitochondrial genome rather than a large genome in the cell nucleus.

This opens up a whole new genome and is a target for new interventions. Lee, along with Pinchas Cohen, a professor of gerontology, medicine and biological sciences and dean of the USC Leonard Davis School, first described evolutionarily conserved proteins and their effects. Metabolism in 2015.

Lee’s subsequent work showed that mitochondrial-encoded MOTS-c directs proteins to interact with the nuclear genome and plays an important role in the regulation of cell metabolism and stress response.

In this study, the research team found that injections of MOTS-c varied by measuring physical fitness and performance in young (2 months), middle-aged (12 months), and old (22 months). We tested how it affects age mice. mouse.

When mice are presented with physical challenges, such as maintaining balance on a rotating rod or running on an accelerating treadmill, mice of all ages treated with MOTS-c are untreated mice of the same age. Was much better than.

Even the group of mice fed a high-fat diet showed significant physical improvement after MOTS-c treatment and gained less weight than untreated mice. These findings reflect previous studies of MOTS-c treatment in mice and have also found that they reverse diet-induced obesity and diet and age-dependent insulin resistance.

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